Mendelian randomization
Mendelian randomization (MR) is a term that applies to the use of genetic variation to
address causal questions about how modifiable exposures influence different outcomes …
address causal questions about how modifiable exposures influence different outcomes …
Using Mendelian randomization analysis to better understand the relationship between mental health and substance use: a systematic review
JL Treur, MR Munafò, E Logtenberg… - Psychological …, 2021 - cambridge.org
BackgroundPoor mental health has consistently been associated with substance use
(smoking, alcohol drinking, cannabis use, and consumption of caffeinated drinks). To …
(smoking, alcohol drinking, cannabis use, and consumption of caffeinated drinks). To …
Testing and correcting for weak and pleiotropic instruments in two‐sample multivariable Mendelian randomization
Multivariable Mendelian randomization (MVMR) is a form of instrumental variable analysis
which estimates the direct effect of multiple exposures on an outcome using genetic variants …
which estimates the direct effect of multiple exposures on an outcome using genetic variants …
Evaluating the relationship between alcohol consumption, tobacco use, and cardiovascular disease: A multivariable Mendelian randomization study
Background Alcohol consumption and smoking, 2 major risk factors for cardiovascular
disease (CVD), often occur together. The objective of this study is to use a wide range of …
disease (CVD), often occur together. The objective of this study is to use a wide range of …
Bias correction for inverse variance weighting Mendelian randomization
Inverse‐variance weighted two‐sample Mendelian randomization (IVW‐MR) is the most
widely used approach that utilizes genome‐wide association studies (GWAS) summary …
widely used approach that utilizes genome‐wide association studies (GWAS) summary …
Cognitive performance protects against Alzheimer's disease independently of educational attainment and intelligence
Y Hu, Y Zhang, H Zhang, S Gao, L Wang, T Wang… - Molecular …, 2022 - nature.com
Mendelian-randomization (MR) studies using large-scale genome-wide association studies
(GWAS) have identified causal association between educational attainment and Alzheimer's …
(GWAS) have identified causal association between educational attainment and Alzheimer's …
Pleiotropy robust methods for multivariable Mendelian randomization
Mendelian randomization is a powerful tool for inferring the presence, or otherwise, of
causal effects from observational data. However, the nature of genetic variants is such that …
causal effects from observational data. However, the nature of genetic variants is such that …
Independent associations of education, intelligence, and cognition with hypertension and the mediating effects of Cardiometabolic risk factors: a Mendelian …
Background: Education, intelligence, and cognition are associated with hypertension, but
which one plays the most prominent role in the pathogenesis of hypertension and which …
which one plays the most prominent role in the pathogenesis of hypertension and which …
Robust multivariable Mendelian randomization based on constrained maximum likelihood
Mendelian randomization (MR) is a powerful tool for causal inference with observational
genome-wide association study (GWAS) summary data. Compared to the more commonly …
genome-wide association study (GWAS) summary data. Compared to the more commonly …
Investigating the impact of poverty on mental illness in the UK Biobank using Mendelian randomization
It is unclear whether poverty and mental illness are causally related. Using UK Biobank and
Psychiatric Genomic Consortium data, we examined evidence of causal links between …
Psychiatric Genomic Consortium data, we examined evidence of causal links between …