Emerging photodynamic nanotherapeutics for inducing immunogenic cell death and potentiating cancer immunotherapy

S Zhang, J Wang, Z Kong, X Sun, Z He, B Sun, C Luo… - Biomaterials, 2022 - Elsevier
Immunotherapy has emerged as a promising cancer treatment modality. Despite the rapid
progress in cancer immunotherapy, the therapeutic efficiency and clinical translation of …

Engineered nanomaterials for synergistic photo-immunotherapy

R Guo, S Wang, L Zhao, Q Zong, T Li, G Ling, P Zhang - Biomaterials, 2022 - Elsevier
Nanomaterial-synergized photodynamic therapy (PDT) and photothermal therapy (PTT), as
efficient and non-invasive treatment modalities, have shown significant advantages in …

Copackaging photosensitizer and PD-L1 siRNA in a nucleic acid nanogel for synergistic cancer photoimmunotherapy

Y Guo, Q Zhang, Q Zhu, J Gao, X Zhu, H Yu, Y Li… - Science …, 2022 - science.org
Packaging multiple drugs into a nanocarrier with rational design to achieve synergistic
cancer therapy remains a challenge due to the intrinsically varied pharmacodynamics of …

A Microenvironment Dual‐Responsive Nano‐Drug Equipped with PD‐L1 Blocking Peptide Triggers Immunogenic Pyroptosis for Prostate Cancer Self‐Synergistic …

H Wang, Z Gao, D Jiao, Y Zhang… - Advanced Functional …, 2023 - Wiley Online Library
Induction of immunogenic cell death (ICD) in tumor combined with immune checkpoint
blockade (ICB) therapy is widely developed to improve the efficacy of cancer …

[HTML][HTML] Photodynamic therapy combined with immunotherapy: Recent advances and future research directions

M Warszyńska, P Repetowski, JM Dąbrowski - Coordination Chemistry …, 2023 - Elsevier
Innovative anticancer therapies based on the activation of the immune system offer promise
in the battle against cancers resistant to traditional treatments. Examples of such therapeutic …

[HTML][HTML] Pure drug nano-assemblies: A facile carrier-free nanoplatform for efficient cancer therapy

S Fu, G Li, W Zang, X Zhou, K Shi, Y Zhai - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Nanoparticulate drug delivery systems (Nano-DDSs) have emerged as possible solution to
the obstacles of anticancer drug delivery. However, the clinical outcomes and translation are …

Self‐blockade of PD‐L1 with bacteria‐derived outer‐membrane vesicle for enhanced cancer immunotherapy

J Pan, X Li, B Shao, F Xu, X Huang, X Guo… - Advanced …, 2022 - Wiley Online Library
The checkpoint inhibitor therapy that blocks programmed death‐1 (PD‐1) and its major
ligand PD‐L1 has achieved encouraging clinical efficacy in certain cancers. However, the …

Biomimetic nanoemulsion for synergistic photodynamic‐immunotherapy against hypoxic breast tumor

Y Zhang, Y Liao, Q Tang, J Lin… - Angewandte Chemie, 2021 - Wiley Online Library
Photodynamic therapy (PDT) is commonly used as an “in situ vaccine” to enhance the
response rate of PD‐1/PD‐L1 antibodies. Unfortunately, the high cost and adverse effects of …

Fenton reaction-based nanomedicine in cancer chemodynamic and synergistic therapy

X Meng, X Zhang, M Liu, B Cai, N He, Z Wang - Applied Materials Today, 2020 - Elsevier
The recently developed reactive oxygen species (ROS)-manipulated nanocatalytic medicine
in cancer treatment based on the Fenton reaction, defined as chemodynamic therapy (CDT) …

Cancer-cell-biomimetic Upconversion nanoparticles combining chemo-photodynamic therapy and CD73 blockade for metastatic triple-negative breast cancer

F **, J Qi, D Liu, Y You, G Shu, Y Du, J Wang… - Journal of Controlled …, 2021 - Elsevier
Photodynamic therapy (PDT) and chemotherapy show clinical promise in destroying
orthotopic tumors but are insufficient against abscopal metastases. The research reports the …