Hypoxia is the critical feature of the tumor microenvironment that is known to lead to
resistance to many chemotherapeutic drugs. Six novel ruthenium (II) anthraquinone …

The redox‐active transition metal copper is an essential trace element for growth and
development and serves as a structural or catalytic cofactor for many enzymes in a range of …

The synthesis of new bis (thiosemicarbazonato) copper (II) complexes featuring polyamine
substituents via selective transamination reactions is presented. Polyamines of different …

ABSTRACT Use of [18 F] FDG-positron emission tomography (PET) in clinical breast cancer
(BC) imaging is limited mainly by insufficient expression levels of facilitative glucose …

Two sulfadiazine azo-azomethine dyes containing two active coordination centers and their
bi-homonuclear UO_2 (II)-complexes were synthesized for potential chemotherapeutic use …

In the present work, a copper–tirapazamine (TPZ) nanocomplex [Cu (TPZ) 2] was
synthesized for selective hypoxia-targeted therapy. The nanocomplex revealed a crystalline …

Since its first description in 1955, tumor hypoxia has become a central issue in cancer
treatment. Since then, it is essential to diagnose accurately the tumor oxygenation degree in …

Synthesis, complex stability and small animal PET imaging of a novel 64 Cu-labelled cryptand
molecule - MedChemComm (RSC Publishing) DOI:10.1039/C4MD00174E Royal Society of …

Objective: Application of distinct positron emission tomography (PET) scan reconstruction
algorithms can lead to statistically significant differences in measuring lesion functional …

Hypoxia prodrugs have become an emerging topic in cancer therapeutics. Tirapazamine
(TPZ) is the most advanced and potent hypoxia prodrug to date, but its clinical outcome has …