Glaucoma, the second most common cause of blindness, is characterized by a progressive
loss of retinal ganglion cells and their axons, with a concomitant loss of the visual field …

Retinal ganglion cells (RGC) bear the sole responsibility of propagating visual stimuli to the
brain. Their axons, which make up the optic nerve, project from the retina to the brain …

Recent evidence suggests that capillary pericytes are contractile and play a crucial role in
the regulation of microcirculation. However, failure to detect components of the contractile …

Dendrite pathology and synapse disassembly are critical features of chronic
neurodegenerative diseases. In spite of this, the capacity of injured neurons to regenerate …

Background The maintenance of complex dendritic arbors and synaptic transmission are
processes that require a substantial amount of energy. Bioenergetic decline is a prominent …

The fate of retinal ganglion cells after optic nerve injury has been thoroughly described in
rat, but not in mice, despite the fact that this species is amply used as a model to study …

Deficits in mitochondrial transport are a common feature of neurodegenerative diseases. We
investigated whether loss of components of the mitochondrial transport machinery im**e …

Purpose.: To assess the effect of a single intravitreal injection of brain-derived neurotrophic
factor (BDNF) on the survival of mouse retinal ganglion cells (RGCs) and on phagocytic …

Purpose.: We characterized the morphologic and functional changes in optic nerve crushed
mice and evaluated electroretinogram (ERG) responses as tools to monitor retinal ganglion …

Increasing evidence indicates that pericytes are vulnerable cells, playing pathophysiological
roles in various neurodegenerative processes. Microvascular pericytes contract during …