Clinical experiences with systemically administered siRNA-based therapeutics in cancer
Small interfering RNA (siRNA)-based therapies are emerging as a promising new
anticancer approach, and a small number of Phase I clinical trials involving patients with …
anticancer approach, and a small number of Phase I clinical trials involving patients with …
RNA interference-based therapy and its delivery systems
X Chen, LS Mangala, C Rodriguez-Aguayo… - Cancer and Metastasis …, 2018 - Springer
RNA interference (RNAi) is considered a highly specific approach for gene silencing and
holds tremendous potential for treatment of various pathologic conditions such as …
holds tremendous potential for treatment of various pathologic conditions such as …
Differential fates of biomolecules delivered to target cells via extracellular vesicles
Extracellular vesicles (EVs), specifically exosomes and microvesicles (MVs), are presumed
to play key roles in cell–cell communication via transfer of biomolecules between cells. The …
to play key roles in cell–cell communication via transfer of biomolecules between cells. The …
Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver
Systemically delivered lipid nanoparticles are preferentially taken up by hepatocytes. This
hinders the development of effective, non-viral means of editing genes in tissues other than …
hinders the development of effective, non-viral means of editing genes in tissues other than …
Therapeutic potentials of gene silencing by RNA interference: principles, challenges, and new strategies
Y Deng, CC Wang, KW Choy, Q Du, J Chen, Q Wang… - Gene, 2014 - Elsevier
During recent decades there have been remarkable advances in biology, in which one of
the most important discoveries is RNA interference (RNAi). RNAi is a specific post …
the most important discoveries is RNA interference (RNAi). RNAi is a specific post …
Photoacoustic image-guided biomimetic nanoparticles targeting rheumatoid arthritis
J Chen, S Zeng, Q Xue, Y Hong, L Liu… - Proceedings of the …, 2022 - National Acad Sciences
The high level of reactive oxygen species (ROS) in the rheumatoid arthritis (RA)
microenvironment (RAM) and its persistent inflammatory nature can promote damage to …
microenvironment (RAM) and its persistent inflammatory nature can promote damage to …
Recent advances in targeted delivery of non-coding RNA-based therapeutics for atherosclerosis
X Li, H Qi, W Cui, Z Wang, X Fu, T Li, H Ma, Y Yang… - Molecular Therapy, 2022 - cell.com
Cardiovascular disease (CVD) has overtaken infectious illnesses as the leading cause of
mortality and disability worldwide. The pathology that underpins CVD is atherosclerosis …
mortality and disability worldwide. The pathology that underpins CVD is atherosclerosis …
[HTML][HTML] RNA interference as a novel treatment strategy for chronic hepatitis B infection
Chronic hepatitis B (CHB) is a major cause of liver-related morbidity and mortality.
Functional cure of CHB, defined as sustainable hepatitis B surface antigen (HBsAg) …
Functional cure of CHB, defined as sustainable hepatitis B surface antigen (HBsAg) …
Progress toward in vivo use of siRNAs-II
GR Rettig, MA Behlke - Molecular therapy, 2012 - cell.com
RNA interference (RNAi) has been extensively employed for in vivo research since its use
was first demonstrated in mammalian cells 10 years ago. Design rules have improved, and it …
was first demonstrated in mammalian cells 10 years ago. Design rules have improved, and it …
First-in-human mutation-targeted siRNA phase Ib trial of an inherited skin disorder
SA Leachman, RP Hickerson, ME Schwartz… - Molecular Therapy, 2010 - cell.com
The rare skin disorder pachyonychia congenita (PC) is an autosomal dominant syndrome
that includes a disabling plantar keratoderma for which no satisfactory treatment is currently …
that includes a disabling plantar keratoderma for which no satisfactory treatment is currently …