Members of the mammalian protein kinase C (PKC) superfamily play key regulatory roles in
a multitude of cellular processes, ranging from control of fundamental cell autonomous …

Phosphoinositide-specific phospholipase C (PLC) subtypes β, γ, and δ comprise a related
group of multidomain phosphodiesterases that cleave the polar head groups from inositol …

The dominant view of protein structure-function is that an amino acid sequence specifies a
three-dimensional (3-D) structure that is a prerequisite for protein function. In contrast, many …

Intracellular vesicle trafficking is the fundamental process to maintain the homeostasis of
membrane-enclosed organelles in eukaryotic cells. These organelles transport cargo from …

Phosphatidic acid (PA) is a critical phospholipid constituent in eukaryotic cell membranes,
which accounts for 1À4% of the total lipid. 1 This lipophilic glycerophospholipid has a …

The C2 domain is a Ca2+‐binding motif of approximately 130 residues in length originally
identified in the Ca2+‐dependent isoforms of protein kinase C. Single and multiple copies of …

A vast amount of protein sequence data accumulated over recent years has revealed that
protein modules are widespread in nature. Many intracellular and extracellular proteins …

Neuronal precursor cell-expressed developmentally downregulated 4 (Nedd4) is the
prototypical protein in a family of E3 ubiquitin ligases that have a common domain …

Protein kinase C has been in the spotlight since the discovery two decades ago that is
activated by the lipid second messenger diacylglycerol. Despite protein kinase C's enduring …

Phosphatidic acid and phosphatidylserine are negatively charged abundant phospholipids
with well-recognized structural roles in cellular membranes. They are also signaling lipids …