Emerging COX-2 inhibitors-based nanotherapeutics for cancer diagnosis and treatment

R Huang, Y Jiang, B Zhang, X Li, H Liu, Y Wang - Biomaterials, 2024 - Elsevier
Increasing evidence has showed that tumorigenesis is closely linked to inflammation,
regulated by multiple signaling pathways. Among these, the cyclooxygenase …

[HTML][HTML] Pyrimidine derivatives as selective COX-2 inhibitors with anti-inflammatory and antioxidant properties

B Tylińska, A Janicka-Kłos… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Pyrimidine derivatives exhibit a wide range of biological activities, including anti-
inflammatory properties. The aim of this study was to investigate the effects of tested …

[HTML][HTML] Unveiling the link between chronic inflammation and cancer

S Tripathi, Y Sharma, D Kumar - Metabolism Open, 2025 - Elsevier
The highly nuanced transition from an inflammatory process to tumorigenesis is of great
scientific interest. While it is well known that environmental stimuli can cause inflammation …

Synthesis of Acetaminophen‐Based Coumarins as Selective COX‐2 Inhibitors: An in vitro‐in silico Study

MHM Jasim, YF Mustafa - Chemistry & Biodiversity, 2024 - Wiley Online Library
Acetaminophen, a centrally‐acting old analgesic drug, is a weak inhibitor of cyclooxygenase
(COX) isoforms with some selectivity toward COX‐2. This compound was used in this work …

In silico anti-cancer activity evaluation of C− N cyclometalated 2H-indazole Ru (II) and Ir (III) complexes via induced DNA disrupting potential

TS Prathima, K Chanda, MM Balamurali - Inorganica Chimica Acta, 2024 - Elsevier
A series of Ru (II) and Ir (III) complexes with C− N cyclometalated 2H-indazole ligands were
examined for their potential as anti-cancer agents. Molecular dynamic simulations were …

COX‐2 Inhibitor Prediction With KNIME: A Codeless Automated Machine Learning‐Based Virtual Screening Workflow

P Ghosh, A Kumar, SK Singh - Journal of Computational …, 2025 - Wiley Online Library
ABSTRACT Cyclooxygenase‐2 (COX‐2) is an enzyme that plays a crucial role in
inflammation by converting arachidonic acid into prostaglandins. The overexpression of …

Novel coumarins from green sweet bell pepper seeds: Their isolation, characterization, oxidative stress-mitigating, anticancer, anti-inflammatory, and antidiabetic …

AH Younes, YF Mustafa - Journal of Molecular Structure, 2024 - Elsevier
In an attempt to develop a potent, eco-friendly, and selective technique for isolating natural
coumarins, this study introduced a novel extraction technique called kinetic thermomagnetic …

Association of COX-inhibitors with cancer patients' survival under chemotherapy and radiotherapy regimens: a real-world data retrospective cohort analysis

LE Flausino, IN Ferreira, WJ Tuan… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Introduction We conducted an extensive, sex-oriented real-world data analysis to explore
the impact and safety of non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX …

Immunohistochemical Expression Levels of Epidermal Growth Factor Receptor, Cyclooxygenase-2, and Ki-67 in Canine Cutaneous Squamous Cell Carcinomas

JM Luís, R Files, C Cardoso, J Pimenta, G Maia… - Current Issues in …, 2024 - mdpi.com
Squamous cell carcinoma (SCC) stands as the second most prevalent skin cancer in dogs,
primarily attributed to UV radiation exposure. Affected areas typically include regions with …

The COX-2 Inhibitor Celecoxib Sensitizes Nasopharyngeal Carcinoma Cells to Ferroptosis

D Li, S Guo, K Wang, Z Liu, T Yu… - Current Cancer Drug …, 2025 - benthamdirect.com
Background Nasopharyngeal cancer [NPC] is prevalent in Southeast Asia and North Africa,
and is generally associated with limited treatment options and poor patient prognosis …