Emerging COX-2 inhibitors-based nanotherapeutics for cancer diagnosis and treatment
R Huang, Y Jiang, B Zhang, X Li, H Liu, Y Wang - Biomaterials, 2024 - Elsevier
Increasing evidence has showed that tumorigenesis is closely linked to inflammation,
regulated by multiple signaling pathways. Among these, the cyclooxygenase …
regulated by multiple signaling pathways. Among these, the cyclooxygenase …
[HTML][HTML] Pyrimidine derivatives as selective COX-2 inhibitors with anti-inflammatory and antioxidant properties
B Tylińska, A Janicka-Kłos… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Pyrimidine derivatives exhibit a wide range of biological activities, including anti-
inflammatory properties. The aim of this study was to investigate the effects of tested …
inflammatory properties. The aim of this study was to investigate the effects of tested …
[HTML][HTML] Unveiling the link between chronic inflammation and cancer
The highly nuanced transition from an inflammatory process to tumorigenesis is of great
scientific interest. While it is well known that environmental stimuli can cause inflammation …
scientific interest. While it is well known that environmental stimuli can cause inflammation …
Synthesis of Acetaminophen‐Based Coumarins as Selective COX‐2 Inhibitors: An in vitro‐in silico Study
Acetaminophen, a centrally‐acting old analgesic drug, is a weak inhibitor of cyclooxygenase
(COX) isoforms with some selectivity toward COX‐2. This compound was used in this work …
(COX) isoforms with some selectivity toward COX‐2. This compound was used in this work …
In silico anti-cancer activity evaluation of C− N cyclometalated 2H-indazole Ru (II) and Ir (III) complexes via induced DNA disrupting potential
TS Prathima, K Chanda, MM Balamurali - Inorganica Chimica Acta, 2024 - Elsevier
A series of Ru (II) and Ir (III) complexes with C− N cyclometalated 2H-indazole ligands were
examined for their potential as anti-cancer agents. Molecular dynamic simulations were …
examined for their potential as anti-cancer agents. Molecular dynamic simulations were …
COX‐2 Inhibitor Prediction With KNIME: A Codeless Automated Machine Learning‐Based Virtual Screening Workflow
ABSTRACT Cyclooxygenase‐2 (COX‐2) is an enzyme that plays a crucial role in
inflammation by converting arachidonic acid into prostaglandins. The overexpression of …
inflammation by converting arachidonic acid into prostaglandins. The overexpression of …
Novel coumarins from green sweet bell pepper seeds: Their isolation, characterization, oxidative stress-mitigating, anticancer, anti-inflammatory, and antidiabetic …
AH Younes, YF Mustafa - Journal of Molecular Structure, 2024 - Elsevier
In an attempt to develop a potent, eco-friendly, and selective technique for isolating natural
coumarins, this study introduced a novel extraction technique called kinetic thermomagnetic …
coumarins, this study introduced a novel extraction technique called kinetic thermomagnetic …
Association of COX-inhibitors with cancer patients' survival under chemotherapy and radiotherapy regimens: a real-world data retrospective cohort analysis
LE Flausino, IN Ferreira, WJ Tuan… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Introduction We conducted an extensive, sex-oriented real-world data analysis to explore
the impact and safety of non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX …
the impact and safety of non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX …
Immunohistochemical Expression Levels of Epidermal Growth Factor Receptor, Cyclooxygenase-2, and Ki-67 in Canine Cutaneous Squamous Cell Carcinomas
JM Luís, R Files, C Cardoso, J Pimenta, G Maia… - Current Issues in …, 2024 - mdpi.com
Squamous cell carcinoma (SCC) stands as the second most prevalent skin cancer in dogs,
primarily attributed to UV radiation exposure. Affected areas typically include regions with …
primarily attributed to UV radiation exposure. Affected areas typically include regions with …
The COX-2 Inhibitor Celecoxib Sensitizes Nasopharyngeal Carcinoma Cells to Ferroptosis
D Li, S Guo, K Wang, Z Liu, T Yu… - Current Cancer Drug …, 2025 - benthamdirect.com
Background Nasopharyngeal cancer [NPC] is prevalent in Southeast Asia and North Africa,
and is generally associated with limited treatment options and poor patient prognosis …
and is generally associated with limited treatment options and poor patient prognosis …