Interoceptive pathways may be manipulated at various levels to develop interventions to
improve symptoms in a range of disorders. Primarily through the lens of the respiratory …

Discovered as a peptide involved in releasing growth hormone, ghrelin was initially
characterized as the “hunger hormone.” However, emerging research indicates that ghrelin …

Ghrelin is a peptide that is produced by endocrine cells that are primarily localized in the
stomach. Ghrelin receptors (GHSR) are expressed in the brain and periphery. Preclinical …

Alcohol use disorder (AUD) is a leading cause of morbidity and mortality worldwide.
However, treatment options, including pharmacotherapies, are limited in number and …

Background Food addiction may play a role in rising obesity rates in connection with
obesogenic environments and processed food availability, however the concept of food …

BACKGROUND The stomach-derived hormone ghrelin stimulates appetite, but the ghrelin
receptor is also expressed in brain circuits involved in motivation and reward. We examined …

The stress response is an adaptive means of maintaining physiological homeostasis in the
face of changing environmental conditions. However, protracted recruitment of stress …

The gut microbiome modulates neurochemical function and behavior and has been
implicated in numerous central nervous system (CNS) diseases, including developmental …

Compounds known to be successful in the treatment of alcohol use disorder include the
aversive agent, Disulfiram, the glutamatergic NMDA receptor antagonist, Acamprosate, and …

The stomach-derived hormone ghrelin plays not only a role in feeding, starvation, and
survival, but it has been suggested to also be involved in the stress response, in …