Abstract Nrf2: INrf2 (Keap1) are cellular sensors of oxidative and electrophilic stress. Nrf2 is
a nuclear factor that controls the expression and coordinated induction of a battery of genes …

Exposure to antioxidants and xenobiotics triggers the expression of a myriad of genes
encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer …

The present study addresses existing data on the affinity and conjugation of sulfhydryl (thiol;-
SH) groups of low-and high-molecular-weight biological ligands with mercury (Hg). The …

Abstract Nuclear Factor-Erythroid Factor 2 (Nrf2) is an important transcription factor that
regulates the expression of large number of genes in healthy and disease states. Nrf2 is …

Cap'n'collar (Cnc) transcription factors are conserved in metazoans and have important
developmental and homeostatic functions. The vertebrate Nrf1, Nrf2, and Nrf3; the …

The TOR kinase, which is present in the functionally distinct complexes TORC1 and TORC2,
is essential for growth but associated with disease and aging. Elucidation of how TOR …

The eukaryotic 26S proteasome is a large multisubunit complex that degrades the majority
of proteins in the cell under normal conditions. The 26S proteasome can be divided into two …

The ubiquitin–proteasome system (UPS) is the primary selective degradation system in the
nuclei and cytoplasm of eukaryotic cells, required for the turnover of myriad soluble proteins …

The transcription factor nuclear factor erythroid-derived 2-like 2 (NRF2) participates in the
activation of the antioxidant cytoprotective pathway and other important physiological …

Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment
increases with age leading to dysregulation of molecular pathways linked to mitochondria …