Less than a decade ago, it was shown that bromodomains, acetyl lysine 'reader'modules
found in proteins with varied functions, were highly tractable small-molecule targets. This is …

The development of bioactive small molecules as probes or drug candidates requires
discovery platforms that enable access to chemical diversity and can quickly reveal new …

DNA-encoded library technology (DELT) was introduced to our medicinal chemistry society
more than 20 years ago. The application of DELT in the development of clinical candidates …

The world is totally dependent on medications. As science progresses, new, better, and
cheaper drugs are needed more than ever. The pharmaceutical industry has been …

Bromodomains (BRDs) are conserved protein interaction modules which recognize (read)
acetyl-lysine modifications, however their role (s) in regulating cellular states and their …

The bromodomain acts to recognize acetylated lysine in histones and transcription proteins
and plays a fundamental role in chromatin-based cellular processes including gene …

With the bromodomain (BRD) inhibitor JQ1, a remarkable success story of BRD4 as a novel
drug target has been set off that yielded many anti‐cancer drugs that are now in clinical …

Bispecific degraders (PROTACs) of ERα are expected to be advantageous over current
inhibitors of ERα signaling (aromatase inhibitors/SERMs/SERDs) used to treat ER+ breast …

The use of a proper encoding methodology is one of the most important aspects when
practicing DEL technology. A “headpiece”‐based double‐stranded DEL encoding method is …

The importance of Discoidin Domain Receptor 1 (DDR1) in renal fibrosis has been shown
via gene knockout and use of antisense oligonucleotides; however, these techniques act via …