A guide to complement biology, pathology and therapeutic opportunity

DC Mastellos, G Hajishengallis… - Nature Reviews …, 2024 - nature.com
Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

Novel Antibody-Based Protection/Therapeutics in Staphylococcus aureus

X Chen, D Missiakas - Annual Review of Microbiology, 2024 - annualreviews.org
Staphylococcus aureus is a commensal of the skin and nares of humans as well as the
causative agent of infections associated with significant mortality. The acquisition of …

Vaccines and monoclonal antibodies to prevent healthcare-associated bacterial infections

L Sauvat, PO Verhoeven, J Gagnaire… - Clinical Microbiology …, 2024 - journals.asm.org
Healthcare-associated infections (HAIs) represent a burden for public health with a high
prevalence and high death rates associated with them. Pathogens with a high potential for …

Dual-mode colorimetric and fluorescence biosensors for the detection of foodborne bacteria

RO Saleh, S Mansouri, A Hammoud, P Rodrigues… - Clinica Chimica …, 2024 - Elsevier
Due to the growing demand for detection technologies, there has been significant interest in
the development of integrated dual-modal sensing technologies, which involve combining …

Multimodal nanoimmunotherapy engages neutrophils to eliminate Staphylococcus aureus infections

J Zhu, R **e, R Gao, Y Zhao, N Yodsanit, M Zhu… - Nature …, 2024 - nature.com
The increasing prevalence of antimicrobial resistance in Staphylococcus aureus
necessitates alternative therapeutic approaches. Neutrophils play a crucial role in the fight …

Peptide clustering enhances large-scale analyses and reveals proteolytic signatures in mass spectrometry data

E Hartman, F Forsberg, S Kjellström, J Petrlova… - Nature …, 2024 - nature.com
Recent advances in mass spectrometry-based peptidomics have catalyzed the identification
and quantification of thousands of endogenous peptides across diverse biological systems …

Ultrasound‐Stimulated “Exocytosis” by Cell‐Like Microbubbles Enhances Antibacterial Species Penetration and Immune Activation Against Implant Infection

W **u, X Li, Q Li, M Ding, Y Zhang, L Wan… - Advanced …, 2024 - Wiley Online Library
Host immune systems serving as crucial defense lines are vital resisting mechanisms
against biofilm‐associated implant infections. Nevertheless, biofilms hinder the penetration …

Viscoelastic and antimicrobial dental care bioplastic with recyclable life cycle

W Choi, U Mangal, JH Yu, JH Ryu, JY Kim… - Nature …, 2024 - nature.com
Medical plastic-appliance-based healthcare services, especially in dentistry, generate
tremendous amounts of plastic waste. Given the physiological features of our mouth, it is …

Virulence attributes of successful methicillin-resistant Staphylococcus aureus lineages

JH Jiang, DR Cameron, C Nethercott… - Clinical microbiology …, 2023 - Am Soc Microbiol
Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of severe and often
fatal infections. MRSA epidemics have occurred in waves, whereby a previously successful …

Mechanochemically reprogrammed interface orchestrates neutrophil bactericidal activity and apoptosis for preventing implant‐associated infection

G Chu, M Guan, J **, Y Luo, Z Luo, T Shi… - Advanced …, 2024 - Wiley Online Library
The onset of implant‐associated infection (IAI) triggers a cascade of immune responses,
which are initially dominated by neutrophils. Bacterial aggregate formation and hypoxic …