A guide to complement biology, pathology and therapeutic opportunity
Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …
Novel Antibody-Based Protection/Therapeutics in Staphylococcus aureus
X Chen, D Missiakas - Annual Review of Microbiology, 2024 - annualreviews.org
Staphylococcus aureus is a commensal of the skin and nares of humans as well as the
causative agent of infections associated with significant mortality. The acquisition of …
causative agent of infections associated with significant mortality. The acquisition of …
Vaccines and monoclonal antibodies to prevent healthcare-associated bacterial infections
L Sauvat, PO Verhoeven, J Gagnaire… - Clinical Microbiology …, 2024 - journals.asm.org
Healthcare-associated infections (HAIs) represent a burden for public health with a high
prevalence and high death rates associated with them. Pathogens with a high potential for …
prevalence and high death rates associated with them. Pathogens with a high potential for …
Dual-mode colorimetric and fluorescence biosensors for the detection of foodborne bacteria
Due to the growing demand for detection technologies, there has been significant interest in
the development of integrated dual-modal sensing technologies, which involve combining …
the development of integrated dual-modal sensing technologies, which involve combining …
Multimodal nanoimmunotherapy engages neutrophils to eliminate Staphylococcus aureus infections
The increasing prevalence of antimicrobial resistance in Staphylococcus aureus
necessitates alternative therapeutic approaches. Neutrophils play a crucial role in the fight …
necessitates alternative therapeutic approaches. Neutrophils play a crucial role in the fight …
Peptide clustering enhances large-scale analyses and reveals proteolytic signatures in mass spectrometry data
E Hartman, F Forsberg, S Kjellström, J Petrlova… - Nature …, 2024 - nature.com
Recent advances in mass spectrometry-based peptidomics have catalyzed the identification
and quantification of thousands of endogenous peptides across diverse biological systems …
and quantification of thousands of endogenous peptides across diverse biological systems …
Ultrasound‐Stimulated “Exocytosis” by Cell‐Like Microbubbles Enhances Antibacterial Species Penetration and Immune Activation Against Implant Infection
Host immune systems serving as crucial defense lines are vital resisting mechanisms
against biofilm‐associated implant infections. Nevertheless, biofilms hinder the penetration …
against biofilm‐associated implant infections. Nevertheless, biofilms hinder the penetration …
Viscoelastic and antimicrobial dental care bioplastic with recyclable life cycle
Medical plastic-appliance-based healthcare services, especially in dentistry, generate
tremendous amounts of plastic waste. Given the physiological features of our mouth, it is …
tremendous amounts of plastic waste. Given the physiological features of our mouth, it is …
Virulence attributes of successful methicillin-resistant Staphylococcus aureus lineages
Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of severe and often
fatal infections. MRSA epidemics have occurred in waves, whereby a previously successful …
fatal infections. MRSA epidemics have occurred in waves, whereby a previously successful …
Mechanochemically reprogrammed interface orchestrates neutrophil bactericidal activity and apoptosis for preventing implant‐associated infection
G Chu, M Guan, J **, Y Luo, Z Luo, T Shi… - Advanced …, 2024 - Wiley Online Library
The onset of implant‐associated infection (IAI) triggers a cascade of immune responses,
which are initially dominated by neutrophils. Bacterial aggregate formation and hypoxic …
which are initially dominated by neutrophils. Bacterial aggregate formation and hypoxic …