A guide to complement biology, pathology and therapeutic opportunity

DC Mastellos, G Hajishengallis… - Nature Reviews …, 2024 - nature.com
Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

Staphylococcus aureus colonisation and strategies for decolonisation

P Piewngam, M Otto - The Lancet Microbe, 2024 - thelancet.com
Staphylococcus aureus is a leading cause of death by infectious diseases worldwide.
Treatment of S aureus infections is difficult due to widespread antibiotic resistance …

Multimodal nanoimmunotherapy engages neutrophils to eliminate Staphylococcus aureus infections

J Zhu, R **e, R Gao, Y Zhao, N Yodsanit, M Zhu… - Nature …, 2024 - nature.com
The increasing prevalence of antimicrobial resistance in Staphylococcus aureus
necessitates alternative therapeutic approaches. Neutrophils play a crucial role in the fight …

Metal-based nanomaterials with enzyme-like characteristics for bacterial rapid detection and control

B Gao, Q Ye, Y Ding, Y Wu, X Zhao, M Deng… - Coordination Chemistry …, 2024 - Elsevier
Bacterial contamination exists in all links of the food industry chain, and bacterial infections
in clinical treatment have become a major problem in the field of global public health …

Mechanochemically reprogrammed interface orchestrates neutrophil bactericidal activity and apoptosis for preventing implant‐associated infection

G Chu, M Guan, J **, Y Luo, Z Luo, T Shi… - Advanced …, 2024 - Wiley Online Library
The onset of implant‐associated infection (IAI) triggers a cascade of immune responses,
which are initially dominated by neutrophils. Bacterial aggregate formation and hypoxic …

Staphylococcus aureus Infections and Human Intestinal Microbiota

A Liu, S Garrett, W Hong, J Zhang - Pathogens, 2024 - mdpi.com
Staphylococcus aureus (S. aureus) is a common pathogen that can cause many human
diseases, such as skin infection, food poisoning, endocarditis, and sepsis. These diseases …

Novel membrane-targeting isoxanthohumol-amine conjugates for combating methicillin-resistant Staphylococcus aureus (MRSA) infections

R Yang, W Cheng, M Huang, T Xu, M Zhang… - European Journal of …, 2024 - Elsevier
Methicillin-resistant Staphylococcus aureus (MRSA) is a widespread pathogen causing
clinical infections and is multi-resistant to many antibiotics, making it urgent need to develop …

Understanding the intricacies of microbial biofilm formation and its endurance in chronic infections: a key to advancing biofilm-targeted therapeutic strategies

FP Dsouza, S Dinesh, S Sharma - Archives of Microbiology, 2024 - Springer
Bacterial biofilms can adhere to various surfaces in the environment with human beings
being no exception. Enclosed in a self-secreted matrix which contains extracellular …

[HTML][HTML] In vitro models for studying implant-associated biofilms-A review from the perspective of bioengineering 3D microenvironments

S Cometta, DW Hutmacher, L Chai - Biomaterials, 2024 - Elsevier
Biofilm research has grown exponentially over the last decades, arguably due to their
contribution to hospital acquired infections when they form on foreign body surfaces such as …

Metabolic modulation-mediated antibiotic and Immune activation for treatment of chronic lung infections

W **u, H Dong, X Chen, L Wan, L Lu, K Yang… - ACS …, 2024 - ACS Publications
The Pseudomonas aeruginosa biofilm in recalcitrant chronic lung infections not only
develops high antimicrobial tolerance but also induces an aberrant host inflammatory …