▪ Abstract At the interface between the innate and adaptive immune systems lies the high-
output isoform of nitric oxide synthase (NOS2 or iNOS). This remarkable molecular machine …

Studying the metabolism of immune cells in recent years has emphasized the tight link
existing between the metabolic state and the phenotype of these cells. Macrophages in …

Phagocyte-derived reactive oxygen and nitrogen species are of crucial importance for host
resistance to microbial pathogens. Decades of research have provided a detailed …

With a molecular weight of 30 nitric oxide (NO) 1 is certainly one of the smallest biological
molecular mediators. In mammalian cells, NO is produced along with l-citrulline by the …

The role of redox molecules, such as NO and ROS, as key mediators of immunity has
recently garnered renewed interest and appreciation. To regulate immune responses, these …

Review of myeloperoxidase supporting optimal microbicidal activity in the phagosomes of
human neutrophils. Successful immune defense requires integration of multiple effector …

Cerebral malaria is the most severe neurological complication of infection with Plasmodium
falciparum. With> 575,000 cases annually, children in sub-Saharan Africa are the most …

Innate immune receptors have a key role in immune surveillance by sensing
microorganisms and initiating protective immune responses. However, the innate immune …

Since its discovery as a biologically active molecule in the late 1980s, nitric oxide (NO) has
been found to play an important role as signal molecule in many parts of the organism as …

Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …