The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …

Platelets—blood cells continuously produced from megakaryocytes mainly in the bone
marrow—are implicated not only in haemostasis and arterial thrombosis, but also in other …

The lung is the primary organ targeted by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), making respiratory failure a leading coronavirus disease 2019 (COVID-19) …

The pathophysiology of COVID-19–associated thrombosis seems to be multifactorial. We
hypothesized that COVID-19 is accompanied by procoagulant platelets with subsequent …

Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100
years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence …

Sepsis is a complex syndrome with a high incidence, increasing by 8.7% annually over the
last 20 years. Coagulopathy is a leading factor associated with mortality in patients with …

Thrombin is a multifunctional serine protease generated in injured cells. The generation of
thrombin in coagulation plays a central role in the functioning of haemostasis. The last …

The physiological heterogeneity of platelets leads to diverse responses and the formation of
discrete subpopulations upon platelet stimulation. Procoagulant platelets are an example of …

Platelets, small anucleate cells circulating in the blood, are critical mediators in haemostasis
and thrombosis. Interestingly, recent studies demonstrated that platelets contain both pro …

Platelets play a variety of roles in vascular biology and are best recognized as primary
hemostasis and thrombosis mediators. Platelets have a large number of receptors and …