Accumulating evidence implicates metabolites produced by gut microbes as crucial
mediators of diet-induced host-microbial cross-talk. Here, we review emerging data …

Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and
indole pathways. A variety of bioactive compounds produced via Trp metabolism can …

The environment, diet, microbiota and body's metabolism shape complex biological
processes in health and disease. However, our understanding of the molecular pathways …

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is
activated by small molecules provided by the diet, microorganisms, metabolism, and …

Complex interactions between the host and the gut microbiota govern intestinal homeostasis
but remain poorly understood. Here we reveal a relationship between gut microbiota and …

Background & Aims Based largely on results from preclinical studies, the concept of a brain
gut microbiome axis has been established, mediating bidirectional communication between …

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best
known for mediating the toxicity and tumour-promoting properties of the carcinogen 2, 3, 7, 8 …

The gut microbiota plays a significant role in the progression of fatty liver disease; however,
the mediators and their mechanisms remain to be elucidated. Comparing metabolite profile …

During the past decade, research has revealed that the vast community of micro-organisms
that inhabit the gut—known as the gut microbiota—is intricately linked to human health and …

Background & Aims Administration of tryptophan and some of its metabolites reduces the
severity of colitis in mice, whereas removing tryptophan from the diet increases susceptibility …