Molecular mechanisms of neuroinflammation in aging and Alzheimer's disease progression

FL Andronie-Cioara, AI Ardelean… - International journal of …, 2023 - mdpi.com
Aging is the most prominent risk factor for late-onset Alzheimer's disease. Aging associates
with a chronic inflammatory state both in the periphery and in the central nervous system, the …

The role of mitochondria in neurodegenerative diseases: the lesson from Alzheimer's disease and Parkinson's disease

G Monzio Compagnoni, A Di Fonzo, S Corti… - Molecular …, 2020 - Springer
Although the pathogenesis of neurodegenerative diseases is still widely unclear, various
mechanisms have been proposed and several pieces of evidence are supportive for an …

[HTML][HTML] Physical activity and brain health

CM Di Liegro, G Schiera, P Proia, I Di Liegro - Genes, 2019 - mdpi.com
Physical activity (PA) has been central in the life of our species for most of its history, and
thus shaped our physiology during evolution. However, only recently the health …

Oxidative stress, synaptic dysfunction, and Alzheimer's disease

E Tönnies, E Trushina - Journal of Alzheimer's disease, 2017 - journals.sagepub.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure. Most
AD cases are sporadic where age represents the greatest risk factor. Lack of understanding …

A perspective on multi-target drug discovery and design for complex diseases

RR Ramsay, MR Popovic-Nikolic, K Nikolic… - Clinical and translational …, 2018 - Springer
Diseases of infection, of neurodegeneration (such as Alzheimer's and Parkinson's
diseases), and of malignancy (cancers) have complex and varied causative factors. Modern …

[HTML][HTML] The brain as an insulin-sensitive metabolic organ

JL Milstein, HA Ferris - Molecular Metabolism, 2021 - Elsevier
Background The brain was once thought of as an insulin-insensitive organ. We now know
that the insulin receptor is present throughout the brain and serves important functions in …

The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing

Y Liu, Y Tan, Z Zhang, M Yi, L Zhu, W Peng - Translational …, 2024 - Springer
Ageing is a crucial risk factor for Alzheimer's disease (AD) and is characterised by systemic
changes in both intracellular and extracellular microenvironments that affect the entire body …

Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and …

L Vaillant-Beuchot, A Mary, R Pardossi-Piquard… - Acta …, 2021 - Springer
Several lines of recent evidence indicate that the amyloid precursor protein-derived C-
terminal fragments (APP-CTFs) could correspond to an etiological trigger of Alzheimer's …

Mitochondrial structure and function in human heart failure

A Hinton Jr, SM Claypool, K Neikirk, N Senoo… - Circulation …, 2024 - ahajournals.org
Despite clinical and scientific advancements, heart failure is the major cause of morbidity
and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the …

Chronic stress weakens connectivity in the prefrontal cortex: architectural and molecular changes

E Woo, LH Sansing, AFT Arnsten, D Datta - Chronic Stress, 2021 - journals.sagepub.com
Chronic exposure to uncontrollable stress causes loss of spines and dendrites in the
prefrontal cortex (PFC), a recently evolved brain region that provides top-down regulation of …