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Molecular mechanisms of neuroinflammation in aging and Alzheimer's disease progression
FL Andronie-Cioara, AI Ardelean… - International journal of …, 2023 - mdpi.com
Aging is the most prominent risk factor for late-onset Alzheimer's disease. Aging associates
with a chronic inflammatory state both in the periphery and in the central nervous system, the …
with a chronic inflammatory state both in the periphery and in the central nervous system, the …
The role of mitochondria in neurodegenerative diseases: the lesson from Alzheimer's disease and Parkinson's disease
G Monzio Compagnoni, A Di Fonzo, S Corti… - Molecular …, 2020 - Springer
Although the pathogenesis of neurodegenerative diseases is still widely unclear, various
mechanisms have been proposed and several pieces of evidence are supportive for an …
mechanisms have been proposed and several pieces of evidence are supportive for an …
[HTML][HTML] Physical activity and brain health
Physical activity (PA) has been central in the life of our species for most of its history, and
thus shaped our physiology during evolution. However, only recently the health …
thus shaped our physiology during evolution. However, only recently the health …
Oxidative stress, synaptic dysfunction, and Alzheimer's disease
E Tönnies, E Trushina - Journal of Alzheimer's disease, 2017 - journals.sagepub.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure. Most
AD cases are sporadic where age represents the greatest risk factor. Lack of understanding …
AD cases are sporadic where age represents the greatest risk factor. Lack of understanding …
A perspective on multi-target drug discovery and design for complex diseases
Diseases of infection, of neurodegeneration (such as Alzheimer's and Parkinson's
diseases), and of malignancy (cancers) have complex and varied causative factors. Modern …
diseases), and of malignancy (cancers) have complex and varied causative factors. Modern …
[HTML][HTML] The brain as an insulin-sensitive metabolic organ
JL Milstein, HA Ferris - Molecular Metabolism, 2021 - Elsevier
Background The brain was once thought of as an insulin-insensitive organ. We now know
that the insulin receptor is present throughout the brain and serves important functions in …
that the insulin receptor is present throughout the brain and serves important functions in …
The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing
Ageing is a crucial risk factor for Alzheimer's disease (AD) and is characterised by systemic
changes in both intracellular and extracellular microenvironments that affect the entire body …
changes in both intracellular and extracellular microenvironments that affect the entire body …
Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and …
Several lines of recent evidence indicate that the amyloid precursor protein-derived C-
terminal fragments (APP-CTFs) could correspond to an etiological trigger of Alzheimer's …
terminal fragments (APP-CTFs) could correspond to an etiological trigger of Alzheimer's …
Mitochondrial structure and function in human heart failure
Despite clinical and scientific advancements, heart failure is the major cause of morbidity
and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the …
and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the …
Chronic stress weakens connectivity in the prefrontal cortex: architectural and molecular changes
Chronic exposure to uncontrollable stress causes loss of spines and dendrites in the
prefrontal cortex (PFC), a recently evolved brain region that provides top-down regulation of …
prefrontal cortex (PFC), a recently evolved brain region that provides top-down regulation of …