Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …

Cancer is the second leading cause of death worldwide and disease burden is expected to
increase globally throughout the next several decades, with the majority of cancer-related …

Chromosomal instability (CIN) generates micronuclei—aberrant extranuclear structures that
catalyze the acquisition of complex chromosomal rearrangements present in cancer …

Oncogene-induced replication stress is a crucial driver of genomic instability and one of the
key events contributing to the onset and evolution of cancer. Despite its critical role in …

Aneuploidy is a hallmark of human cancer, yet the molecular mechanisms to cope with
aneuploidy-induced cellular stresses remain largely unknown. Here, we induce …

Aneuploidy is defined as the cellular state of having a number of chromosomes that deviates
from a multiple of the normal haploid chromosome number of a given organism. Aneuploidy …

Confined cell migration hampers genome integrity and activates the ATR and ATM mechano-
transduction pathways. We investigated whether the mechanical stress generated by …

Aneuploidy—the karyotype state in which the number of chromosomes deviates from a
multiple of the haploid chromosome set—is common in cancer, where it is thought to …

Chromosomal instability (CIN), an increased rate of changes in chromosome structure and
number, is observed in most sporadic human carcinomas with high metastatic activity. Here …

Chromosomal instability (CIN) is the persistent reshuffling of cancer karyotypes via
chromosome mis-segregation during cell division. In cancer, CIN exists at varying levels that …