[HTML][HTML] Minimization of parathyroid hormone: novel amino-terminal parathyroid hormone fragments with enhanced potency in activating the type-1 parathyroid …

M Shimizu, JT Potts Jr, TJ Gardella - Journal of Biological Chemistry, 2000 - Elsevier
The amino-terminal and carboxyl-terminal portions of the 1–34 fragment of parathyroid
hormone (PTH) contain the major determinants of receptor activation and receptor binding …

The (1–14) fragment of parathyroid hormone (PTH) activates intact and amino-terminally truncated PTH-1 receptors

MD Luck, PH Carter, TJ Gardella - Molecular Endocrinology, 1999 - academic.oup.com
Recent mutagenesis and cross-linking studies suggest that residues in the carboxyl-terminal
portion of PTH (1–34) interact with the amino-terminal extracellular domain of the receptor …

PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules

TJ Gardella, HM Kronenberg, JT Potts Jr… - US Patent …, 2006 - Google Patents
Novel parathyroid hormone (PTH) peptides and analogs thereof of the PTH (1-34) fragment
are disclosed that com bine the N-terminal signaling domain (residues 1-9) and the C …

Modified human parathyroid hormone

FR Bringhurst, H Takasu, TJ Gardella… - US Patent …, 2002 - Google Patents
The present invention is related to novel Synthetic and/or recombinant biologically active
peptide derivatives of par athyroid hormone (PTH). In particular, the invention relates to PTH …

Conformationally constrained parathyroid hormone (PTH) analogs

TJ Gardella - US Patent 7,572,765, 2009 - Google Patents
The present invention relates to conformationally constrained parathyroid hormone (PTH)
analogs, and methods of prepar ing and using the PTH analogs. The invention provides …

Nucleic acids encoding PTH functional domain conjugate peptides

TJ Gardella, HM Kronenberg, JT Potts Jr… - US Patent …, 2007 - Google Patents
Novel parathyroid hormone (PTH) peptides and analogs thereof of the PTH (1-34) fragment
are disclosed that com bine the N-terminal signaling domain (residues 1-9) and the C …

Human parathyroid hormone modifications, preparation and use

FR Bringhurst, H Takasu, TJ Gardella… - US Patent …, 2009 - Google Patents
US7479478B2 - Human parathyroid hormone modifications, preparation and use - Google
Patents US7479478B2 - Human parathyroid hormone modifications, preparation and use …

Nucleic acids encoding modified parathyroid hormone

FR Bringhurst, H Takasu, TJ Gardella… - US Patent …, 2004 - Google Patents
US6803213B2 - Nucleic acids encoding modified parathyroid hormone - Google Patents
US6803213B2 - Nucleic acids encoding modified parathyroid hormone - Google Patents …

Receptors for parathyroid hormone (PTH) and PTH-related peptide

TJ Gardella, H Jüppner, FR Bringhurst… - Principles of bone …, 2002 - Elsevier
Publisher Summary The biological actions of parathyroid hormone (PTH) and parathyroid
hormone-related protein (PTHrP) have attracted wider interest in recent years because of …

Polypeptide derivatives of parathyroid hormone (PTH)

TJ Gardella, HM Kronenberg, JT Potts Jr… - US Patent …, 2006 - Google Patents
Novel parathyroid hormone (PTH) polypeptide derivatives are disclosed, as are
pharmaceutical compositions contain ing said polypeptides, and synthetic and recombinant …