Application and prospects of butylphthalide for the treatment of neurologic diseases

XQ Chen, K Qiu, H Liu, Q He, JH Bai… - Chinese medical journal, 2019 - mednexus.org
Objective: The 3-N-butylphthalide (NBP) comprises one of the chemical constituents of
celery oil. It has a series of pharmacologic mechanisms including reconstructing …

DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress

B Wang, C Wu, Z Chen, P Zheng, Y Liu… - Acta pharmacologica …, 2021 - nature.com
Abstract DL-3-n-Butylphthalide (DL-NBP), a small molecular compound extracted from the
seeds of Apium graveolens Linn (Chinese celery), has been shown to exert neuroprotective …

Depression and anxiety in the epilepsies: from bench to bedside

V Krishnan - Current neurology and neuroscience reports, 2020 - Springer
Abstract Purpose of Review Depression and anxiety substantially contribute to interictal
disability in patients with epilepsy (PWE). This review summarizes current studies that shed …

Klotho alleviates NLRP3 inflammasome-mediated neuroinflammation in a temporal lobe epilepsy rat model by activating the Nrf2 signaling pathway

T ** Review
TYC Tan, XY Lim, NA Norahmad, H Chanthira Kumar… - Molecules, 2023 - mdpi.com
Apium graveolens is an indigenous plant in the family Apiaceae, or Umbelliferae, that
contains many active compounds. It has been used traditionally to treat arthritic conditions …

Efficacy of sequential N-butylphthalide therapy on psychiatric and behavioral functions in acute ischemic stroke

L Yang, H Li, Y Wu, H Zhang, J Du, Y Chen - Medicine, 2021 - journals.lww.com
Background: Stroke can cause physical and mental problems. This study examined how the
sequential therapy of N-butylphthalide (NBP) could effectively improve physical movement …