One‐pot and two‐pot methods for chalcone derived pyrimidines synthesis and applications
Chalcone‐derived pyrimidine is a well‐known heterocyclic compound that is commonly
present in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) bio‐isosteres …
present in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) bio‐isosteres …
Discovery of highly potent tubulin polymerization inhibitors: Design, synthesis, and structure-activity relationships of novel 2, 7-diaryl-[1, 2, 4] triazolo [1, 5-a] …
XS Huo, XE Jian, J Ou-Yang, L Chen, F Yang… - European Journal of …, 2021 - Elsevier
Abstract By removing 5-methyl and 6-acetyl groups in our previously reported compound 3,
we designed a series of novel 2, 7-diaryl-[1, 2, 4] triazolo [1, 5-a] pyrimidine derivatives as …
we designed a series of novel 2, 7-diaryl-[1, 2, 4] triazolo [1, 5-a] pyrimidine derivatives as …
Antibacterial and molecular docking studies of newly synthesized nucleosides and Schiff bases derived from sulfadimidines
A new series of nucleosides, moieties, and Schiff bases were synthesized from
sulfadimidine. Infrared (IR), 1HNMR, 13C NMR, and mass spectrometry techniques and …
sulfadimidine. Infrared (IR), 1HNMR, 13C NMR, and mass spectrometry techniques and …
Discovery and optimization of 2, 3-diaryl-1, 3-thiazolidin-4-one-based derivatives as potent and selective cytotoxic agents with anti-inflammatory activity
Several studies have indicated the potential therapeutic outcomes of combining selective
COX-2 inhibitors with tubulin-targeting anticancer agents. In the current study, a novel series …
COX-2 inhibitors with tubulin-targeting anticancer agents. In the current study, a novel series …
[HTML][HTML] Anticancer activity, spectroscopic and molecular docking of some new synthesized sugar hydrazones, Arylidene and α-Aminophosphonate derivatives
In this work, we design and then synthesis of new derivatives of nucleosides, oxadiazoline
derivatives containing acetylated sugars and α-aminophosphonate derivatives. The …
derivatives containing acetylated sugars and α-aminophosphonate derivatives. The …
Morpholine substituted quinazoline derivatives as anticancer agents against MCF-7, A549 and SHSY-5Y cancer cell lines and mechanistic studies
A series of morpholine substituted quinazoline derivatives have been synthesized and
evaluated for cytotoxic potential against A549, MCF-7 and SHSY-5Y cancer cell lines. These …
evaluated for cytotoxic potential against A549, MCF-7 and SHSY-5Y cancer cell lines. These …
Synthesis and screening of novel 4-N-heterocyclic-2-aryl-6, 7, 8-trimethoxyquinazolines as antiproliferative and tubulin polymerization inhibitors
Colchicine binding site represent a crucial target for the anticancer drug development
especially in view of emerging drug resistance from the currently available …
especially in view of emerging drug resistance from the currently available …
Benzotriazole Substituted 2-Phenylquinazolines as Anticancer Agents: Synthesis, Screening, Antiproliferative and Tubulin Polymerization Inhibition Activity
Aims: Development of anticancer agents targeting tubulin protein. Background: Tubulin
protein is being explored as an important target for anticancer drug development. Ligands …
protein is being explored as an important target for anticancer drug development. Ligands …
Papain-Decorated Mucopenetrating SEDDS: A Tentative Approach to Combat Absorption Issues of Acyclovir via the Oral Route
The aim of the current study was to enhance the oral bioavailability of Acyclovir (ACV) based
on the papain-functionalized self-emulsifying drug delivery systems (SEDDS). The optimum …
on the papain-functionalized self-emulsifying drug delivery systems (SEDDS). The optimum …
KOtBu-mediated transition-metal-free synthesis of pyrimidines by selective three-component coupling reactions: A mechanistic insight
F Wang, Z Deng, Y Wang, F Yuan, X Zhang, GP Lu… - Tetrahedron, 2022 - Elsevier
A KO t Bu-mediated strategy for pyrimidine synthesis via selective three-component coupling
reactions has been disclosed. This chemistry, in which a series of pyrimidines (20 examples) …
reactions has been disclosed. This chemistry, in which a series of pyrimidines (20 examples) …