A saturation-mutagenesis analysis of the interplay between stability and activation in Ras

F Hidalgo, LM Nocka, NH Shah, K Gorday… - Elife, 2022 - elifesciences.org
Cancer mutations in Ras occur predominantly at three hotspots: Gly 12, Gly 13, and Gln 61.
Previously, we reported that deep mutagenesis of H-Ras using a bacterial assay identified …

Local Xenon–Protein Interaction Produces Global Conformational Change and Allosteric Inhibition in Lysozyme

J He, IJ Dmochowski - Biochemistry, 2023 - ACS Publications
Noble gases have well-established biological effects, yet their molecular mechanisms
remain poorly understood. Here, we investigated, both experimentally and computationally …