Significance: Mitochondria are the energetic, metabolic, redox, and information signaling
centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae …

Epidemiological studies in humans suggest that skeletal muscle aging is a risk factor for the
development of several age‐related diseases such as metabolic syndrome, cancer, A …

Elucidating brain cell type specific gene expression patterns is critical towards a better
understanding of how cell-cell communications may influence brain functions and …

Idiopathic inflammatory myopathies (IIMs) are severe autoimmune diseases with poorly
understood pathogenesis and unmet medical needs. Here, we examine the role of interferon …

Large-scale meta-analyses of genome-wide association studies (GWAS) have identified>
175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high …

Transcriptional coregulators (coactivators and corepressors) have emerged as the principal
modulators of the functions of nuclear receptors and other transcription factors. During the …

Background Androgens are anabolic steroid hormones that exert their function by binding to
the androgen receptor (AR). We have previously established that AR deficiency in limb …

Cannabis has potential therapeutic use but tetrahydrocannabinol (THC), its main
psychoactive component, appears as a risk factor for ischemic stroke in young adults. We …

Recent evidence indicates that skeletal muscle influences systemic aging, but little is known
about the signaling pathways and muscle-released cytokines (myokines) responsible for this …

Exposure to environmental cues such as cold or nutritional imbalance requires white
adipose tissue (WAT) to adapt its metabolism to ensure survival. Metabolic plasticity is …