Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
[HTML][HTML] Diabetes mellitus—Progress and opportunities in the evolving epidemic
Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads
to complications that reduce quality of life and increase mortality. Diabetes pathophysiology …
to complications that reduce quality of life and increase mortality. Diabetes pathophysiology …
Design principles of microneedles for drug delivery and sampling applications
Microneedles technology is a powerful platform to achieve efficient transdermal delivery of
bioactive molecules for local or systemic therapies attributing to their minimally invasive …
bioactive molecules for local or systemic therapies attributing to their minimally invasive …
Glucose metabolism-inspired catalytic patches for NIR-II phototherapy of diabetic wound infection
Medical patches hold great prospects for diabetic wound administration, while their practical
effects in diabetic wound management remain mired by the complexity of wound …
effects in diabetic wound management remain mired by the complexity of wound …
ZnT8 loss-of-function accelerates functional maturation of hESC-derived β cells and resists metabolic stress in diabetes
Human embryonic stem cell-derived β cells (SC-β cells) hold great promise for treatment of
diabetes, yet how to achieve functional maturation and protect them against metabolic …
diabetes, yet how to achieve functional maturation and protect them against metabolic …
Primary human organoids models: Current progress and key milestones
During the past 10 years the world has experienced enormous progress in the organoids
field. Human organoids have shown huge potential to study organ development …
field. Human organoids have shown huge potential to study organ development …
PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development
HH Lau, NAJ Krentz, F Abaitua… - Nature …, 2023 - nature.com
The coding variant (p. Arg192His) in the transcription factor PAX4 is associated with an
altered risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for …
altered risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for …
The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α
Abstract Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of
insulin producing pancreatic β-cells. One of the genes associated with T1D is TYK2, which …
insulin producing pancreatic β-cells. One of the genes associated with T1D is TYK2, which …
Targeting gut microbiota with natural polysaccharides: effective interventions against high-fat diet-induced metabolic diseases
CY Sun, ZL Zheng, CW Chen, BW Lu… - Frontiers in Microbiology, 2022 - frontiersin.org
Unhealthy diet, in particular high-fat diet (HFD) intake, can cause the development of several
metabolic disorders, including obesity, hyperlipidemia, type 2 diabetes mellitus (T2DM), non …
metabolic disorders, including obesity, hyperlipidemia, type 2 diabetes mellitus (T2DM), non …
[HTML][HTML] Making human pancreatic islet organoids: Progresses on the cell origins, biomaterials and three-dimensional technologies
L Jiang, Y Shen, Y Liu, L Zhang, W Jiang - Theranostics, 2022 - ncbi.nlm.nih.gov
Diabetes is one of the most socially challenging health concerns. Even though islet
transplantation has shown promise for insulin-dependent diabetes, there is still no effective …
transplantation has shown promise for insulin-dependent diabetes, there is still no effective …