Late sodium current inhibitors as potential antiarrhythmic agents
Based on recent findings, an increased late sodium current (INa, late) plays an important
pathophysiological role in cardiac diseases, including rhythm disorders. The article first …
pathophysiological role in cardiac diseases, including rhythm disorders. The article first …
Advances in basic and translational research in atrial fibrillation
D Hu, H Barajas-Martinez… - … of the Royal …, 2023 - royalsocietypublishing.org
Atrial fibrillation (AF) is a very common cardiac arrhythmia with an estimated prevalence of
33.5 million patients globally. It is associated with an increased risk of death, stroke and …
33.5 million patients globally. It is associated with an increased risk of death, stroke and …
The HARMONY trial: combined ranolazine and dronedarone in the management of paroxysmal atrial fibrillation: mechanistic and therapeutic synergism
JA Reiffel, AJ Camm, L Belardinelli… - Circulation …, 2015 - Am Heart Assoc
Background—Atrial fibrillation (AF) requires arrhythmogenic changes in atrial ion
channels/receptors and usually altered atrial structure. AF is commonly treated with …
channels/receptors and usually altered atrial structure. AF is commonly treated with …
Ranolazine improves oxidative stress and mitochondrial function in the atrium of acetylcholine-CaCl2 induced atrial fibrillation rats
D Zou, N Geng, Y Chen, LI Ren, X Liu, J Wan, S Guo… - Life Sciences, 2016 - Elsevier
Aims Ranolazine, an antianginal agent used for chronic stable angina treatment, was
demonstrated to be effective in atrial fibrillation (AF) treatment. The aim of this study was to …
demonstrated to be effective in atrial fibrillation (AF) treatment. The aim of this study was to …
Ranolazine for rhythm control in atrial fibrillation: a systematic review and meta-analysis
Background/objectives Available pharmacological options for rhythm control strategy in
atrial fibrillation (AF) are limited by sub-optimal efficacy and potentially serious adverse …
atrial fibrillation (AF) are limited by sub-optimal efficacy and potentially serious adverse …
Arrhythmogenic and antiarrhythmic actions of late sustained sodium current in the adult human heart
Late sodium current (late INa) inhibition has been proposed to suppress the incidence of
arrhythmias generated by pathological states or induced by drugs. However, the role of late …
arrhythmias generated by pathological states or induced by drugs. However, the role of late …
Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes
Background We have previously shown that non-equilibrium Na+ current (I Na) reactivation
drives isoproterenol-induced phase-3 early afterdepolarizations (EADs) in mouse ventricular …
drives isoproterenol-induced phase-3 early afterdepolarizations (EADs) in mouse ventricular …
Anti-arrhythmic strategies for atrial fibrillation: The role of computational modeling in discovery, development, and optimization
Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with increased risk
of cerebrovascular stroke, and with several other pathologies, including heart failure …
of cerebrovascular stroke, and with several other pathologies, including heart failure …
Computational modeling: What does it tell us about atrial fibrillation therapy?
Atrial fibrillation (AF) is a complex cardiac arrhythmia with diverse etiology that negatively
affects morbidity and mortality of millions of patients. Technological and experimental …
affects morbidity and mortality of millions of patients. Technological and experimental …
[PDF][PDF] 12 Vasodilators & the Treatment of Angina Pectoris
BG Katzung, K Chatterjee - Basic & clinical pharmacology, 1989 - academia.edu
A 56-year-old woman presents in the office with a history of recent-onset chest discomfort
when jogging or swimming vigorously. The pain is dull but poorly localized; it disappears …
when jogging or swimming vigorously. The pain is dull but poorly localized; it disappears …