Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …

The growing field of immune metabolism has revealed promising indications for metabolic
targets to modulate anti-cancer immunity. Combination therapies involving metabolic …

Cancer is a leading cause of death worldwide. Surgery is the primary treatment approach for
cancer, but the survival rate is very low due to the rapid progression of the disease and …

Objective Osteosarcoma (OS) is a common bone malignancy with poor prognosis. We
aimed to investigate the relationship between cuproptosis-related lncRNAs (CRLncs) and …

The constant changes in cancer cell bioenergetics are widely known as metabolic
reprogramming. Reprogramming is a process mediated by multiple factors, including …

Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant
free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis …

Simple Summary Dysregulated glutamine metabolism is one of the metabolic features
evident in cancer cells when compared to normal cells. Cancer cells utilize glutamine for …

Drug resistance represents a significant obstacle in cancer treatment, underscoring the need
for the discovery of novel therapeutic targets. Ubiquitin-specific proteases (USPs), a …

Metabolic alterations have been observed in many cancer types. The deregulated
metabolism has thus become an emerging hallmark of the disease, where the metabolism is …

Biguanides are a class of antidiabetic drugs that includes phenformin and metformin;
however, the former was withdrawn from approval in many countries due to its toxicity …