Inflammasomes are multiprotein innate immune complexes that regulate caspase-
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …

Cross-species comparisons of genomes, transcriptomes and gene regulation are now
feasible at unprecedented resolution and throughput, enabling the comparison of human …

Laboratory mice, while paramount for understanding basic biological phenomena, are
limited in modeling complex diseases of humans and other free-living mammals. Because …

Laboratory experiments have uncovered many basic aspects of bacterial physiology and
behavior. After the past century of mostly in vitro experiments, we now have detailed …

In Darwin's and Mendel's times, researchers investigated a wealth of organisms, chosen to
solve particular problems for which they seemed especially well suited. Later, a focus on a …

The laboratory mouse is the workhorse of immunology, used as a model of mammalian
immune function, but how well immune responses of laboratory mice reflect those of free …

The domestication and development of cattle has considerably impacted human societies,
but the histories of cattle breeds and populations have been poorly understood especially …

Background Murine models are a crucial component of gut microbiome research.
Unfortunately, a multitude of genetic backgrounds and experimental setups, together with …

Abstract The Diversity Outbred (DO) population is a heterogeneous stock derived from the
same eight founder strains as the Collaborative Cross (CC) inbred strains. Genetically …

Abstract The JAX Diversity Outbred population is a new mouse resource derived from
partially inbred Collaborative Cross strains and maintained by randomized outcrossing. As …