Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides

J Saarikangas, H Zhao… - Physiological …, 2010 - journals.physiology.org
The plasma membrane and the underlying cortical actin cytoskeleton undergo continuous
dynamic interplay that is responsible for many essential aspects of cell physiology …

[HTML][HTML] Regulation of actin cytoskeleton dynamics in cells

SH Lee, R Dominguez - Molecules and cells, 2010 - Elsevier
The dynamic remolding of the actin cytoskeleton is a critical part of most cellular activities,
and malfunction of cytoskeletal proteins results in various human diseases. The transition …

Mechanisms of actin disassembly and turnover

BL Goode, J Eskin, S Shekhar - Journal of Cell Biology, 2023 - rupress.org
Cellular actin networks exhibit a wide range of sizes, shapes, and architectures tailored to
their biological roles. Once assembled, these filamentous networks are either maintained in …

Cap** protein regulators fine-tune actin assembly dynamics

M Edwards, A Zwolak, DA Schafer, D Sept… - … reviews Molecular cell …, 2014 - nature.com
Cap** protein (CP) binds the fast growing barbed end of the actin filament and regulates
actin assembly by blocking the addition and loss of actin subunits. Recent studies provide …

The yeast actin cytoskeleton: from cellular function to biochemical mechanism

JB Moseley, BL Goode - Microbiology and Molecular Biology …, 2006 - Am Soc Microbiol
All cells undergo rapid remodeling of their actin networks to regulate such critical processes
as endocytosis, cytokinesis, cell polarity, and cell morphogenesis. These events are driven …

MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11

J Bockhorn, R Dalton, C Nwachukwu, S Huang… - Nature …, 2013 - nature.com
Chemotherapy resistance frequently drives tumour progression. However, the underlying
molecular mechanisms are poorly characterized. Epithelial-to-mesenchymal transition has …

Regulation of cytoskeletal dynamics by actin-monomer-binding proteins

VO Paavilainen, E Bertling, S Falck, P Lappalainen - Trends in cell biology, 2004 - cell.com
The actin cytoskeleton is a vital component of several key cellular and developmental
processes in eukaryotes. Many proteins that interact with filamentous and/or monomeric …

miR-206 inhibits stemness and metastasis of breast cancer by targeting MKL1/IL11 pathway

R Samaeekia, V Adorno-Cruz, J Bockhorn… - Clinical Cancer …, 2017 - AACR
Purpose: Effective targeting of cancer stem cells is necessary and important for eradicating
cancer and reducing metastasis-related mortality. Understanding of cancer stemness …

Attenuation of microRNA-1 derepresses the cytoskeleton regulatory protein twinfilin-1 to provoke cardiac hypertrophy

Q Li, XW Song, J Zou, GK Wang… - Journal of cell …, 2010 - journals.biologists.com
MicroRNAs are involved in several aspects of cardiac hypertrophy, including cardiac growth,
conduction, and fibrosis. However, their effects on the regulation of the cardiomyocyte …

Twinfilin uncaps filament barbed ends to promote turnover of lamellipodial actin networks

M Hakala, H Wioland, M Tolonen, T Kotila, A Jegou… - Nature cell …, 2021 - nature.com
Coordinated polymerization of actin filaments provides force for cell migration,
morphogenesis and endocytosis. Cap** protein (CP) is a central regulator of actin …