Drug repurposing for antimicrobial discovery
Antimicrobial resistance continues to be a public threat on a global scale. The ongoing need
to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens …
to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens …
Microbiota–gut–brain axis and epilepsy: a review on mechanisms and potential therapeutics
M Ding, Y Lang, H Shu, J Shao, L Cui - Frontiers in Immunology, 2021 - frontiersin.org
The gut–brain axis refers to the bidirectional communication between the gut and brain, and
regulates intestinal homeostasis and the central nervous system via neural networks and …
regulates intestinal homeostasis and the central nervous system via neural networks and …
Generative AI for designing and validating easily synthesizable and structurally novel antibiotics
The rise of pan-resistant bacteria is creating an urgent need for structurally novel antibiotics.
Artificial intelligence methods can discover new antibiotics, but existing methods have …
Artificial intelligence methods can discover new antibiotics, but existing methods have …
Antibacterial activity of nonantibiotics is orthogonal to standard antibiotics
Numerous nonantibiotic drugs have potent antibacterial activity and can adversely affect the
human microbiome. The mechanistic underpinning of this toxicity remains largely unknown …
human microbiome. The mechanistic underpinning of this toxicity remains largely unknown …
Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance
The increasing use of polymyxins 1 in addition to the dissemination of plasmid-borne colistin
resistance threatens to cause a serious breach in our last line of defence against multidrug …
resistance threatens to cause a serious breach in our last line of defence against multidrug …
The gut microbiome and epilepsy
Recently, evidence from both animal studies and human cases has emerged that a
dysbiosis in the gut may be associated with certain forms of epilepsy. The ketogenic diet is …
dysbiosis in the gut may be associated with certain forms of epilepsy. The ketogenic diet is …
Bacterial Targets of Antibiotics in Methicillin-Resistant Staphylococcus aureus
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most prevalent bacterial
pathogens and continues to be a leading cause of morbidity and mortality worldwide. MRSA …
pathogens and continues to be a leading cause of morbidity and mortality worldwide. MRSA …
Modular assembly of the bacterial large ribosomal subunit
The ribosome is a complex macromolecular machine and serves as an ideal system for
understanding biological macromolecular assembly. Direct observation of ribosome …
understanding biological macromolecular assembly. Direct observation of ribosome …
[HTML][HTML] Psychotropics and the microbiome: a chamber of secrets…
The human gut contains trillions of symbiotic bacteria that play a key role in programming
different aspects of host physiology in health and disease. Psychotropic medications act on …
different aspects of host physiology in health and disease. Psychotropic medications act on …
Structures of the human mitochondrial ribosome in native states of assembly
Mammalian mitochondrial ribosomes (mitoribosomes) have less rRNA content and 36
additional proteins compared with the evolutionarily related bacterial ribosome. These …
additional proteins compared with the evolutionarily related bacterial ribosome. These …