In contrast to the multiple disease-modifying therapies that are available for relapsing–
remitting multiple sclerosis (MS), the therapeutic options for progressive MS (PMS) are …

Multiple sclerosis (MS) is an inflammatory-mediated demyelinating disease of the human
central nervous system. The clinical disease course is variable, usually starts with reversible …

Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system that causes motor, sensory, and cognitive deficits. The present study characterized …

Damage to axons is taken as a key factor of disability in multiple sclerosis, but its
pathogenesis is largely unknown. Axonal injury is believed to occur as a consequence of …

Recent magnetic resonance (MR) studies of multiple sclerosis lesions indicate that axonal
injury is a major correlate of permanent clinical deficit. In the present study we systematically …

Multiple sclerosis is a common cause of neurological disability in young adults. The disease
is complex—its aetiology is multifactorial and largely unknown; its pathology is …

Multiple sclerosis is characterized morphologically by the key features demyelination,
inflammation, gliosis and axonal damage. In recent years, it has become more evident that …

Twenty‐three plaques obtained at early autopsy from 2 patients with secondary‐progressive
multiple sclerosis were examined immunohistochemically for microglia/macrophages, and …

Objective: The impact of present disease‐modifying treatments (DMTs) in multiple sclerosis
(MS) on nerve injury and reactive astrogliosis is still unclear. Therefore, we studied the effect …

Axonal degeneration has been proposed as a cause of irreversible neurological disability in
multiple sclerosis (MS) patients. The purpose of this study was to quantify axonal loss in …