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Defensins: a double-edged sword in host immunity
Defensins are a major family of host defense peptides expressed predominantly in
neutrophils and epithelial cells. Their broad antimicrobial activities and multifaceted …
neutrophils and epithelial cells. Their broad antimicrobial activities and multifaceted …
Vulvovaginal candidiasis: Epidemiology, microbiology and risk factors
Vulvovaginal candidiasis (VVC) is an infection caused by Candida species that affects
millions of women every year. Although Candida albicans is the main cause of VVC, the …
millions of women every year. Although Candida albicans is the main cause of VVC, the …
[HTML][HTML] Immunomodulatory and allergenic properties of antimicrobial peptides
With the growing problem of the emergence of antibiotic-resistant bacteria, the search for
alternative ways to combat bacterial infections is extremely urgent. While analyzing the effect …
alternative ways to combat bacterial infections is extremely urgent. While analyzing the effect …
Chronic endometritis and infertility
HJ Park, YS Kim, TK Yoon… - Clinical and experimental …, 2016 - pmc.ncbi.nlm.nih.gov
Chronic endometritis (CE) is a condition involving the breakdown of the peaceful co-
existence between microorganisms and the host immune system in the endometrium. A …
existence between microorganisms and the host immune system in the endometrium. A …
Does the endometrial cavity have a molecular microbial signature?
Recent molecular studies concluded that the endometrium has a resident microbiota
dominated by Lactobacillus spp. and is therefore similar to that of the vagina. These findings …
dominated by Lactobacillus spp. and is therefore similar to that of the vagina. These findings …
Defensins: antimicrobial peptides of innate immunity
The production of natural antibiotic peptides has emerged as an important mechanism of
innate immunity in plants and animals. Defensins are diverse members of a large family of …
innate immunity in plants and animals. Defensins are diverse members of a large family of …
Role of lactobacilli and lactoferrin in the mucosal cervicovaginal defense
The innate defense system of the female mucosal genital tract involves a close and complex
interaction among the healthy vaginal microbiota, different cells, and various proteins that …
interaction among the healthy vaginal microbiota, different cells, and various proteins that …
The role of cationic antimicrobial peptides in innate host defences
Cationic antimicrobial peptides are found in all living species. A single animal can contain>
24 different antimicrobial peptides, which fall into four structural classes. These peptides are …
24 different antimicrobial peptides, which fall into four structural classes. These peptides are …
Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria
Paneth cells in mouse small intestinal crypts secrete granules rich in microbicidal peptides
when exposed to bacteria or bacterial antigens. The dose-dependent secretion occurs …
when exposed to bacteria or bacterial antigens. The dose-dependent secretion occurs …
Antiviral mechanisms of human defensins
Defensins are an effector component of the innate immune system with broad antimicrobial
activity. Humans express two types of defensins, α-and β-defensins, which have antiviral …
activity. Humans express two types of defensins, α-and β-defensins, which have antiviral …