[HTML][HTML] Mechanisms of insulin action and insulin resistance
The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …
research into insulin action and resistance has issued. In the intervening century, some …
[HTML][HTML] The potential of metabolomics in biomedical applications
The metabolome offers a dynamic, comprehensive, and precise picture of the phenotype.
Current high-throughput technologies have allowed the discovery of relevant metabolites …
Current high-throughput technologies have allowed the discovery of relevant metabolites …
Mendelian randomization in cardiometabolic disease: challenges in evaluating causality
Mendelian randomization (MR) is a burgeoning field that involves the use of genetic variants
to assess causal relationships between exposures and outcomes. MR studies can be …
to assess causal relationships between exposures and outcomes. MR studies can be …
Metabolomics and metabolic diseases: where do we stand?
Metabolomics, or the comprehensive profiling of small molecule metabolites in cells, tissues,
or whole organisms, has undergone a rapid technological evolution in the past two decades …
or whole organisms, has undergone a rapid technological evolution in the past two decades …
Metabolomics in prediabetes and diabetes: a systematic review and meta-analysis
OBJECTIVE To conduct a systematic review of cross-sectional and prospective human
studies evaluating metabolite markers identified using high-throughput metabolomics …
studies evaluating metabolite markers identified using high-throughput metabolomics …
Quantitative serum nuclear magnetic resonance metabolomics in large-scale epidemiology: a primer on-omic technologies
P Würtz, AJ Kangas, P Soininen… - American journal of …, 2017 - academic.oup.com
Detailed metabolic profiling in large-scale epidemiologic studies has uncovered novel
biomarkers for cardiometabolic diseases and clarified the molecular associations of …
biomarkers for cardiometabolic diseases and clarified the molecular associations of …
[HTML][HTML] Metabolomics of type 1 and type 2 diabetes
Type 1 and type 2 diabetes mellitus (DM) are chronic diseases that affect nearly 425 million
people worldwide, leading to poor health outcomes and high health care costs. High …
people worldwide, leading to poor health outcomes and high health care costs. High …
Branched-chain amino acids in metabolic signalling and insulin resistance
Branched-chain amino acids (BCAAs) are important nutrient signals that have direct and
indirect effects. Frequently, BCAAs have been reported to mediate antiobesity effects …
indirect effects. Frequently, BCAAs have been reported to mediate antiobesity effects …
Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future
Glucose metabolism is normally regulated by a feedback loop including islet β cells and
insulin-sensitive tissues, in which tissue sensitivity to insulin affects magnitude of β-cell …
insulin-sensitive tissues, in which tissue sensitivity to insulin affects magnitude of β-cell …
Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics
P Soininen, AJ Kangas, P Würtz, T Suna… - Circulation …, 2015 - ahajournals.org
Metabolomics is becoming common in epidemiology due to recent developments in
quantitative profiling technologies and appealing results from their applications for …
quantitative profiling technologies and appealing results from their applications for …