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Clocks, cancer, and chronochemotherapy
BACKGROUND The core of the mammalian circadian clock mechanism is a time-delayed
transcription-translation feedback loop (TTFL), which influences the transcription and …
transcription-translation feedback loop (TTFL), which influences the transcription and …
Circadian rhythms and exercise—re-setting the clock in metabolic disease
Perturbed diurnal rhythms are becoming increasingly evident as deleterious events in the
pathology of metabolic diseases. Exercise is well characterized as a crucial intervention in …
pathology of metabolic diseases. Exercise is well characterized as a crucial intervention in …
Circadian regulator BMAL1:: CLOCK promotes cell proliferation in hepatocellular carcinoma by controlling apoptosis and cell cycle
Hepatocellular carcinoma (HCC) remains a global health challenge whose incidence is
growing worldwide. Previous evidence strongly supported the notion that the circadian clock …
growing worldwide. Previous evidence strongly supported the notion that the circadian clock …
Molecular architecture of the mammalian circadian clock
Circadian clocks coordinate physiology and behavior with the 24h solar day to provide
temporal homeostasis with the external environment. The molecular clocks that drive these …
temporal homeostasis with the external environment. The molecular clocks that drive these …
Metabolism and exercise: the skeletal muscle clock takes centre stage
Circadian rhythms that influence mammalian homeostasis and overall health have received
increasing interest over the past two decades. The molecular clock, which is present in …
increasing interest over the past two decades. The molecular clock, which is present in …
Cancer and the circadian clock
The circadian clock is a master regulator of mammalian physiology, regulating daily
oscillations of crucial biological processes and behaviors. Notably, circadian disruption has …
oscillations of crucial biological processes and behaviors. Notably, circadian disruption has …
Molecular components of the Mammalian circadian clock
Mammals synchronize their circadian activity primarily to the cycles of light and darkness in
the environment. This is achieved by ocular photoreception relaying signals to the …
the environment. This is achieved by ocular photoreception relaying signals to the …
Circadian rhythm regulates the function of immune cells and participates in the development of tumors
Y Zeng, Z Guo, M Wu, F Chen, L Chen - Cell death discovery, 2024 - nature.com
Circadian rhythms are present in almost all cells and play a crucial role in regulating various
biological processes. Maintaining a stable circadian rhythm is essential for overall health …
biological processes. Maintaining a stable circadian rhythm is essential for overall health …
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β
The circadian clock acts at the genomic level to coordinate internal behavioural and
physiological rhythms via the CLOCK–BMAL1 transcriptional heterodimer. Although the …
physiological rhythms via the CLOCK–BMAL1 transcriptional heterodimer. Although the …
Metabolism and the circadian clock converge
Circadian rhythms occur in almost all species and control vital aspects of our physiology,
from slee** and waking to neurotransmitter secretion and cellular metabolism …
from slee** and waking to neurotransmitter secretion and cellular metabolism …