Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Although substantial progress has been made in the diagnosis and treatment of acute
coronary syndromes, cardiovascular disease remains the leading cause of death globally …

The nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …

Stroke is the second highest cause of death globally and a leading cause of disability, with
an increasing incidence in develo** countries. Ischaemic stroke caused by arterial …

Objective Obesity and its associated comorbidities represent a global health challenge with
a need for well-tolerated, effective, and mechanistically diverse pharmaceutical …

Cardiovascular disease (CVD) is still a leading cause of morbidity and mortality, despite all
the progress achieved as regards to both prevention and treatment. Having high levels of …

Abstract Purpose of Review Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes
mellitus (T2DM) are strongly associated. Both also associate with an increased risk of …

Background The majority of epidemiological studies on migraine have been conducted in a
specific country or region, and there is a lack of globally comparable data. We aim to report …

Background A higher intake of dietary fiber is associated with a decreased risk of chronic
inflammatory diseases such as cardiovascular disease and inflammatory bowel disease …

Background Polypharmacy is one of the most important health issues for its potential
impacts on disease burden and healthcare costs. The aim of this study was to update a …