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Interactions between bacterial and phage communities in natural environments
We commonly acknowledge that bacterial viruses (phages) shape the composition and
evolution of bacterial communities in nature and therefore have important roles in ecosystem …
evolution of bacterial communities in nature and therefore have important roles in ecosystem …
[HTML][HTML] Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein
9) shows the opportunity to treat a diverse array of untreated various genetic and …
9) shows the opportunity to treat a diverse array of untreated various genetic and …
Phage-plasmids promote recombination and emergence of phages and plasmids
Phages and plasmids are regarded as distinct types of mobile genetic elements that drive
bacterial evolution by horizontal gene transfer. However, the distinction between both types …
bacterial evolution by horizontal gene transfer. However, the distinction between both types …
[HTML][HTML] Phages and their satellites encode hotspots of antiviral systems
Bacteria carry diverse genetic systems to defend against viral infection, some of which are
found within prophages where they inhibit competing viruses. Phage satellites pose …
found within prophages where they inhibit competing viruses. Phage satellites pose …
Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity
The cyclic oligonucleotide-based antiphage signalling system (CBASS) and the pyrimidine
cyclase system for antiphage resistance (Pycsar) are antiphage defence systems in diverse …
cyclase system for antiphage resistance (Pycsar) are antiphage defence systems in diverse …
Bacteriophages suppress CRISPR–Cas immunity using RNA-based anti-CRISPRs
Many bacteria use CRISPR–Cas systems to combat mobile genetic elements, such as
bacteriophages and plasmids. In turn, these invasive elements have evolved anti-CRISPR …
bacteriophages and plasmids. In turn, these invasive elements have evolved anti-CRISPR …
Inhibitors of bacterial immune systems: discovery, mechanisms and applications
To contend with the diversity and ubiquity of bacteriophages and other mobile genetic
elements, bacteria have developed an arsenal of immune defence mechanisms. Bacterial …
elements, bacteria have developed an arsenal of immune defence mechanisms. Bacterial …
CRISPR-Cas-based antimicrobials: design, challenges, and bacterial mechanisms of resistance
The emergence of antibiotic-resistant bacterial strains is a source of public health concern
across the globe. As the discovery of new conventional antibiotics has stalled significantly …
across the globe. As the discovery of new conventional antibiotics has stalled significantly …
Microbial evolution through horizontal gene transfer by mobile genetic elements
Mobile genetic elements (MGEs) are crucial for horizontal gene transfer (HGT) in bacteria
and facilitate their rapid evolution and adaptation. MGEs include plasmids, integrative and …
and facilitate their rapid evolution and adaptation. MGEs include plasmids, integrative and …
[HTML][HTML] Global marine microbial diversity and its potential in bioprospecting
The past two decades has witnessed a remarkable increase in the number of microbial
genomes retrieved from marine systems,. However, it has remained challenging to translate …
genomes retrieved from marine systems,. However, it has remained challenging to translate …