Intermediate filaments constitute the third component of the cellular skeleton. Unlike actin
and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of …

Mechanically induced signal transduction has an essential role in development. Cells
actively transduce and respond to mechanical signals and their internal architecture must …

The protein phosphatase 2A (PP2A) heterotrimer PP2A-B56α is a human tumour
suppressor. However, the molecular mechanisms inhibiting PP2A-B56α in cancer are poorly …

Cancer is a pathology characterized by a loss or a perturbation of a number of typical
features of normal cell behaviour. Indeed, the acquisition of an inappropriate migratory and …

The cytolinker and scaffolding protein, plectin, has emerged as a potent driver of malignant
hallmarks in many human cancers due to its involvement in various cellular activities …

Human oral cancer is the single largest group of malignancies in the Indian subcontinent
and the sixth largest group of malignancies worldwide. Squamous cell carcinomas (SCC) …

Mechanical forces may be generated within a cell due to tissue stiffness, cytoskeletal
reorganization, and the changes (even subtle) in the cell's physical surroundings. These …

Nanostructuring is a process involving surface manipulation at the nanometric level, which
improves the mechanical and biological properties of biomaterials. Specifically, it affects the …

The plectin gene can encode a cytoskeletal linking protein, plectin, known for its interaction
with three critical components of the cellular cytoskeleton: intermediate filaments …

Migration and invasion are important characteristics of rheumatoid arthritis fibroblast-like
synoviocytes (RA-FLSs), which are involved in joint damage and contribute to rheumatoid …