Preservation solutions for kidney transplantation: history, advances and mechanisms

Y Chen, J Shi, TC **a, R Xu, X He… - Cell …, 2019 - journals.sagepub.com
Solid organ transplantation was one of the greatest medical advances during the past few
decades. Organ preservation solutions have been applied to diminish ischemic/hypoxic …

[HTML][HTML] Utilizing pathophysiological concepts of ischemia-reperfusion injury to design renoprotective strategies and therapeutic interventions for normothermic ex vivo …

B Ogurlu, TL Hamelink, IM Van Tricht… - American Journal of …, 2024 - Elsevier
Normothermic machine perfusion (NMP) has emerged as a promising tool for the
preservation, viability assessment, and repair of deceased-donor kidneys prior to …

Detrimental effects of prolonged warm renal ischaemia‐reperfusion injury are abrogated by supplemental hydrogen sulphide: an analysis using real‐time intravital …

JXG Zhu, M Kalbfleisch, YX Yang, R Bihari… - BJU …, 2012 - Wiley Online Library
What's known on the subject? and What does the study add? Hydrogen sulphide (H2S) has
recently been classified as a member of the gasotransmitter family. Its physiological and …

Preventive effect of ginger (Zingiber officinale) pretreatment on renal ischemia-reperfusion in rats

S Maghsoudi, A Gol, S Dabiri, A Javadi - European Surgical Research, 2011 - karger.com
Background/Aims: The present study examined the preventive effect of ginger against renal
ischemia-reperfusion (IR) injury. Methods: 30 adultmale rats were used. The animals were …

Neuroprotective effect of gadolinium: a stretch-activated calcium channel blocker in mouse model of ischemia–reperfusion injury

P Gulati, A Muthuraman, AS Jaggi, N Singh - … -Schmiedeberg's archives of …, 2013 - Springer
The present study was designed to investigate the potential of gadolinium, a stretch-
activated calcium channel blocker in ischemic reperfusion (I/R)-induced brain injury in mice …

Ryanodine receptor antagonism protects the ischemic liver and modulates TNF-α and IL-10

F López-Neblina, LH Toledo-Pereyra… - Journal of Surgical …, 2007 - Elsevier
BACKGROUND: Dantrolene is a ryanodine receptor and intracellular calcium antagonist.
The ryanodine receptor (RyR) Ca2+ release channel mobilizes Ca2+ from internal stores to …

Amlodipine alleviates renal ischemia/reperfusion injury in rats through Nrf2/Sestrin2/PGC-1α/TFAM Pathway

H Shirzad, SA Mousavinezhad, M Panji… - BMC Pharmacology and …, 2023 - Springer
Background Previously, observational studies showed that amlodipine can mitigate
calcineurin inhibitor-and contrast-induced acute kidney injury (AKI). Herein, we aimed to …

Study of the protective effect of ischemic and pharmacological preconditioning on hepatic ischemic reperfusion injury induced in rats

AS Osman, AH Osman, MM Kamel - JGH Open, 2017 - Wiley Online Library
Background and Aim Hepatic ischemia reperfusion injury is the main cause of liver failure
following liver surgery, so an effective method is needed to prevent or reduce this hepatic …

Renal ischemia and reperfusion injury: influence of chorpromazine on renal function and lipid peroxidation

S Tucci Junior, RM Carvalho, FM Celini… - Acta Cirurgica …, 2008 - SciELO Brasil
PURPOSE: To evaluate the influence of chlorpromazine (CPZ) on renal function and lipid
peroxidation in a rat model of kidney ischemia/reperfusion injury. METHODS: Forty eight …

Toward the optimal utilization of renal normothermic machine perfusion

TL Hamelink - 2025 - research.rug.nl
The shortage of organ donors has significantly increased waiting times for kidney
transplants. To address this issue and expand the donor pool, suboptimal kidneys—often …