Recent trends and emerging strategies for aptasensing technologies for illicit drugs detection

S Soni, U Jain, DH Burke, N Chauhan - Journal of Electroanalytical …, 2022 - Elsevier
Aptamers are ligand-binding oligonucleotide sequences with high affinities and selectivities
towards their targets. Concomitantly, their excellent recognition property has led to their …

Towards personalized treatment of pain using a quantitative systems pharmacology approach

SC Goulooze, E Krekels, M Van Dijk… - European Journal of …, 2017 - repub.eur.nl
Pain is a complex biopsychosocial phenomenon of which the intensity, location and duration
depends on various underlying components. Treatment of pain is associated with …

Electronic health record–embedded decision support platform for morphine precision dosing in neonates

AA Vinks, NC Punt, F Menke… - Clinical …, 2020 - Wiley Online Library
Morphine is the opioid most commonly used for neonatal pain management. In intravenous
form, it is administered as continuous infusions and intermittent injections, mostly based on …

[HTML][HTML] Implementing physics-based digital patient twins to tailor the switch of oral morphine to transdermal fentanyl patches based on patient physiology

F Bahrami, RM Rossi, K De Nys, M Joerger… - European Journal of …, 2024 - Elsevier
Fentanyl transdermal patches are widely implemented for cancer-induced pain treatment
due to the high potency of fentanyl and gradual drug release. However, transdermal fentanyl …

Advances in pharmacokinetic-pharmacodynamic modelling for pediatric drug development: extrapolations and exposure-response analyses

SC Goulooze, PW Vis, EHJ Krekels… - Expert Review of …, 2023 - Taylor & Francis
ABSTRACT Introduction Pharmacokinetic (PK)-Pharmacodynamic (PD) and exposure-
response (ER) modeling are critical parts of pediatric drug development. By integrating …

Kernel-based visual hazard comparison (kbVHC): a simulation-free diagnostic for parametric repeated time-to-event models

SC Goulooze, PAJ Välitalo, CAJ Knibbe, EHJ Krekels - The AAPS journal, 2018 - Springer
Repeated time-to-event (RTTE) models are the preferred method to characterize the
repeated occurrence of clinical events. Commonly used diagnostics for parametric RTTE …

Epidural oxycodone for acute pain

P Piirainen, H Kokki, M Kokki - Pharmaceuticals, 2022 - mdpi.com
Epidural analgesia is commonly used in labour analgesia and in postoperative pain after
major surgery. It is highly effective in severe acute pain, has minimal effects on foetus and …

Morphine pharmacodynamics in mechanically ventilated preterm neonates undergoing endotracheal suctioning

PA Välitalo, EHJ Krekels, M van Dijk… - CPT …, 2017 - Wiley Online Library
To date, morphine pharmacokinetics (PKs) are well quantified in neonates, but results about
its efficacy are ambiguous. This work presents an analysis of a previously published study …

Comparative efficacy of ketamine, lidocaine, acetaminophen, and dexmedetomidine combined with morphine patient-controlled analgesia in treating opium-addicted …

H Modir, E Moshiri, M Azami, MJ Zad… - Journal of Acute …, 2022 - journals.lww.com
Objective: To compare the effect of ketamine, lidocaine, acetaminophen, and
dexmedetomidine combined with morphine patient-controlled analgesia for opium addicts …

Population pharmacokinetics of oxycodone in plasma and cerebrospinal fluid after epidural and intravenous administration

M Lamminsalo, P Piirainen, H Kokki… - Expert Opinion on …, 2019 - Taylor & Francis
Objectives: To establish the first plasma and cerebrospinal fluid (CSF) oxycodone
population pharmacokinetic (PopPK) model after epidural (EPI) and intravenous (IV) …