A pyrazole nucleus is an easy-to-prepare scaffold with large therapeutic potential.
Consequently, the search for new pyrazole-based compounds is of great interest to the …

P38α (which is also named MAPK14) plays a pivotal role in initiating different disease states
such as inflammatory disorders, neurodegenerative diseases, cardiovascular cases, and …

Pyrazole has been recognized as a pharmacologically important privileged scaffold whose
derivatives produce almost all types of pharmacological activities and have attracted much …

The p38α MAP Kinase has been an important target of drug design for treatment of
inflammatory diseases and cancers. This work applies multiple replica Gaussian …

Abstract Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine
kinase (RTK) and plays pivotal roles in regulating cellular functions such as proliferation …

The p38 family is a highly evolutionarily conserved group of mitogen‐activated protein
kinases (MAPKs) that is involved in and helps co‐ordinate cellular responses to nearly all …

To further extend the structure-activity relationships (SARs) of 5-aminopyrazoles (5APs) and
identify novel compounds able to interfere with inflammation, oxidative stress, and …

P38 mitogen‐activated protein kinase (p38MAPK) is a multifunctional protein kinase that
plays an important role in human normal physiological activities and a variety of major …

Toxoplasmosis is a significant public health concern with limited therapeutic options. The
medicines for malaria venture (MMV) developed the pandemic response box (PRB) …

The simultaneous targeting of neuroinflammation and cholinergic hypofunction, the key
pathological changes in Alzheimer's disease (AD), is not addressed by drugs currently in …