The role of junctophilin proteins in cellular function
Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma
membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR) …
membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR) …
Role of Ca2+ in healthy and pathologic cardiac function: from normal excitation–contraction coupling to mutations that cause inherited arrhythmia
Abstract Calcium (Ca2+) ions are a key second messenger involved in the rhythmic
excitation and contraction of cardiomyocytes throughout the heart. Proper function of Ca2+ …
excitation and contraction of cardiomyocytes throughout the heart. Proper function of Ca2+ …
Targeting calpain-2-mediated junctophilin-2 cleavage delays heart failure progression following myocardial infarction
Coronary heart disease (CHD) is a prevalent cardiac disease that causes over 370,000
deaths annually in the USA. In CHD, occlusion of a coronary artery causes ischemia of the …
deaths annually in the USA. In CHD, occlusion of a coronary artery causes ischemia of the …
[HTML][HTML] Control of Ca2+ and metabolic homeostasis by the Na+/Ca2+ exchangers (NCXs) in health and disease
T Rodrigues, S Piccirillo, S Magi, A Preziuso… - Biochemical …, 2022 - Elsevier
Spatial and temporal control of calcium (Ca 2+) levels is essential for the background
rhythms and responses of living cells to environmental stimuli. Whatever other regulators a …
rhythms and responses of living cells to environmental stimuli. Whatever other regulators a …
Targeting calcium-mediated inter-organellar crosstalk in cardiac diseases
Introduction Abnormal calcium signaling between organelles such as the sarcoplasmic
reticulum (SR), mitochondria and lysosomes is a key feature of heart diseases. Calcium …
reticulum (SR), mitochondria and lysosomes is a key feature of heart diseases. Calcium …
Protective Effects of Allicin on Acute Myocardial Infarction in Rats via Hydrogen Sulfide-mediated Regulation of Coronary Arterial Vasomotor Function and Myocardial …
T Cui, W Liu, C Yu, J Ren, Y Li, X Shi, Q Li… - Frontiers in …, 2022 - frontiersin.org
Acute myocardial infarction (AMI) is a condition with high morbidity and mortality, for which
effective treatments are lacking. Allicin has been reported to exert therapeutic effects on AMI …
effective treatments are lacking. Allicin has been reported to exert therapeutic effects on AMI …
Serine-threonine protein phosphatase regulation of Cx43 dephosphorylation in arrhythmogenic disorders
Regulation of cell-to-cell communication in the heart by the gap junction protein Connexin43
(Cx43) involves modulation of Cx43 phosphorylation state by protein kinases, and …
(Cx43) involves modulation of Cx43 phosphorylation state by protein kinases, and …
Function and regulation of phosphatase 1 in healthy and diseased heart
E Klapproth, S Kämmerer, A El-Armouche - Cellular Signalling, 2022 - Elsevier
Reversible phosphorylation of ion channels and calcium-handling proteins provides precise
post-translational regulation of cardiac excitation and contractility. Serine/threonine …
post-translational regulation of cardiac excitation and contractility. Serine/threonine …
Structure-activity optimization of ryanodine receptor modulators for the treatment of catecholaminergic polymorphic ventricular tachycardia
OM Moore, M Sibrian-Vazquez, JA Navarro-Garcia… - Heart Rhythm, 2024 - Elsevier
Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited
arrhythmia disorder associated with lethal arrhythmias. Most CPVT cases are caused by …
arrhythmia disorder associated with lethal arrhythmias. Most CPVT cases are caused by …
The cardioprotective effects and mechanisms of naringenin in myocardial ischemia based on network pharmacology and experiment verification
Y Yang, J Qi, M Zhang, P Chen, Y Liu, X Sun… - Frontiers in …, 2022 - frontiersin.org
Naringenin (Nar) is a natural flavonoid extracted from citrus fruits with abundant
pharmacological properties against cardiac diseases, but existing studies are unsystematic …
pharmacological properties against cardiac diseases, but existing studies are unsystematic …