Intranasal vaccine: Factors to consider in research and development

H Xu, L Cai, S Hufnagel, Z Cui - International journal of pharmaceutics, 2021 - Elsevier
Most existing vaccines for human use are administered by needle-based injection.
Administering vaccines needle-free intranasally has numerous advantages over by needle …

[PDF][PDF] Liposomal drug delivery: a versatile platform for challenging clinical applications

A Madni, M Sarfraz, M Rehman… - … of Pharmacy & …, 2014 - frontierspartnerships.org
Liposomes are lipid based vesicular systems that offer novel platform for versatile drug
delivery to target cell. Liposomes were first reported by Bangham and his co-workers in …

Mucosal vaccination via the respiratory tract

M Hellfritzsch, R Scherließ - Pharmaceutics, 2019 - mdpi.com
Vaccine delivery via mucosal surfaces is an interesting alternative to parenteral vaccine
administration, as it avoids the use of a needle and syringe. Mucosal vaccine administration …

Lipid-based particles: versatile delivery systems for mucosal vaccination against infection

B Corthésy, G Bioley - Frontiers in immunology, 2018 - frontiersin.org
Vaccination is the process of administering immunogenic formulations in order to induce or
harness antigen (Ag)-specific antibody and T cell responses in order to protect against …

Recent advances in respiratory immunization: A focus on COVID-19 vaccines

X He, X Chen, H Wang, G Du, X Sun - Journal of Controlled Release, 2023 - Elsevier
The development of vaccines has always been an essential task worldwide since vaccines
are regarded as powerful weapons in protecting the global population. Although the vast …

Induction of protective immune responses at respiratory mucosal sites

SC Park, MJ Wiest, V Yan, PT Wong… - Human Vaccines & …, 2024 - Taylor & Francis
Many pathogens enter the host through mucosal sites. Thus, interfering with pathogen entry
through local neutralization at mucosal sites therefore is an effective strategy for preventing …

Carbohydrate immune adjuvants in subunit vaccines

S Bashiri, P Koirala, I Toth, M Skwarczynski - Pharmaceutics, 2020 - mdpi.com
Modern subunit vaccines are composed of antigens and a delivery system and/or adjuvant
(immune stimulator) that triggers the desired immune responses. Adjuvants mimic pathogen …

Intranasal formulations: promising strategy to deliver vaccines

P Riese, P Sakthivel, S Trittel… - Expert opinion on drug …, 2014 - Taylor & Francis
Introduction: The emergence of new diseases and the lack of efficient vaccines against
numerous nontreatable pathogens require the development of novel vaccination strategies …

Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection

RF Foronjy, AJ Dabo, N Cummins, P Geraghty - BMC immunology, 2014 - Springer
Background Respiratory syncytial virus (RSV) infects the lung epithelium where it stimulates
the production of numerous host cytokines that are associated with disease burden and …

Nanoparticles for mucosal vaccine delivery

A Thakur, C Foged - Nanoengineered biomaterials for advanced drug …, 2020 - Elsevier
Mucosal surfaces represent important routes of entry into the human body for the majority of
pathogens, and they constitute unique sites for targeted vaccine delivery. Nanoparticle …