Circular RNA: metabolism, functions and interactions with proteins

WY Zhou, ZR Cai, J Liu, DS Wang, HQ Ju, RH Xu - Molecular cancer, 2020 - Springer
Abstract Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules
that are ubiquitous across species ranging from viruses to mammals. Important advances …

Specific expression and functions of circular RNAs

S Misir, N Wu, BB Yang - Cell Death & Differentiation, 2022 - nature.com
In recent years, circular RNAs (circRNAs), a new class of RNA molecules characterized by
their covalently closed circular structure, have become a new research paradigm in RNA …

Exosome-derived circCCAR1 promotes CD8+ T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma

Z Hu, G Chen, Y Zhao, H Gao, L Li, Y Yin, J Jiang… - Molecular cancer, 2023 - Springer
Abstract Background Circular RNAs (circRNAs) can be encapsulated into exosomes to
participate in intercellular communication, affecting the malignant progression of a variety of …

[HTML][HTML] Review on circular RNAs and new insights into their roles in cancer

X Tang, H Ren, M Guo, J Qian, Y Yang, C Gu - … and structural biotechnology …, 2021 - Elsevier
Circular RNAs (circRNAs) are a very interesting class of conserved single-stranded RNA
molecules derived from exonic or intronic sequences by precursor mRNA back-splicing …

M6A-mediated upregulation of circMDK promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma

A Du, S Li, Y Zhou, C Disoma, Y Liao, Y Zhang, Z Chen… - Molecular cancer, 2022 - Springer
Background Emerging evidence suggest the critical role of circular RNAs (circRNAs) in
disease development especially in various cancers. However, the oncogenic role of …

[HTML][HTML] Circular RNA ACTN4 promotes intrahepatic cholangiocarcinoma progression by recruiting YBX1 to initiate FZD7 transcription

Q Chen, H Wang, Z Li, F Li, L Liang, Y Zou, H Shen… - Journal of …, 2022 - Elsevier
Background & Aims Intrahepatic cholangiocarcinoma (ICC) is a primary liver cancer with
high aggressiveness and extremely poor prognosis. The role of circular RNAs (circRNAs) in …

Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma

X Zhang, Y Xu, L Ma, K Yu, Y Niu, X Xu… - Cancer …, 2022 - Wiley Online Library
Background Resistance to ferroptosis, a regulated cell death caused by iron‐dependent
excessive accumulation of lipid peroxides, has recently been linked to lung adenocarcinoma …

Circular RNA vaccine induces potent T cell responses

L Amaya, L Grigoryan, Z Li, A Lee… - Proceedings of the …, 2023 - National Acad Sciences
Circular RNAs (circRNAs) are a class of RNAs commonly found across eukaryotes and
viruses, characterized by their resistance to exonuclease-mediated degradation. Their …

The functional roles of the circRNA/Wnt axis in cancer

C Xue, G Li, Q Zheng, X Gu, Z Bao, J Lu, L Li - Molecular Cancer, 2022 - Springer
CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of
species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt …

[HTML][HTML] Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer

J Chen, Y Wu, X Luo, D **, W Zhou, Z Ju, D Wang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Background: Tumor metastasis of colorectal cancer (CRC) is the main cause of death in
most patients and the major difficulty in comprehensive CRC treatment. Circular RNAs …