The skeletal system is the basis of the vertebral body composition, which affords stabilization
sites for muscle attachment, protects vital organs, stores mineral ions, supplies places to the …

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and has an
exceedingly low median overall survival of only 15 months. Current standard-of-care for …

Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology, as
it represents a major obstacle to effective cancer treatment. Since tumor cells are highly …

Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of
brain tumors remains a challenge. This is particularly true for the most frequent and fatal …

Acridine Orange is a cell-permeable green fluorophore that can be protonated and trapped
in acidic vesicular organelles (AVOs). Its metachromatic shift to red fluorescence is …

Temozolomide (TMZ), an alkylating agent, is widely used for treating primary and recurrent
high-grade gliomas. However, the efficacy of TMZ is often limited by the development of …

Glioma is one of the most common and lethal brain tumors. Surgical resection followed by
radiotherapy plus chemotherapy is the current standard of care for patients with glioma. The …

Autophagy and the DNA damage response (DDR) are biological processes essential for
cellular and organismal homeostasis. Herein, we summarize and discuss emerging …

Glioblastoma multiforme is the most common and the most aggressive primary brain tumor. It
is characterized by a high degree of hypoxia and also by a remarkable resistance to therapy …

Epithelial-to-mesenchymal transition (EMT) and its reverse process MET naturally occur
during development and in tissue repair in vertebrates. EMT is also recognized as the …