Over the past decades, the bulk of chemists' interests have been on heterocyclic compounds
and their various derivatives as well as their applications in the pharmaceutical and …

The development of new antitumor agents is one of the most pressing research areas in
medicinal chemistry and medicine. The importance of triazole and thiadiazole rings as …

Dihydrofolate reductase (DHFR) inhibitors, as antibacterial agents, contain pyrimidine,
pteridine, and azine moieties among many other scaffolds. Folic acid (FA), with a pteridine …

A series of 5, 5‐diarylhydantoin (Dilantin) 3, 4, and 7, imidazole 1, 2, 5, 6, 8, and 9, thiazole
10–12, triazinthione 13, 15, 16, and 17, and thiadiazine 14 derivatives, containing diverse …

A one-pot, three-component route for the synthesis of novel 1, 3, 4-thiadiazole derivatives
using a ketene S, S-acetal, a carbonyl compound and thiocarbohydrazide is described. The …

Background: 1, 3, 4-thiadiazoles, 1, 3, 4-thiadiazines and thienopyrimidines have newly
attracted attention due to their forceful pharmacological activities. They showed …

A series of novel 4‐amino‐5‐mercapto‐3‐[(3‐aralkyl amido/imidoalkyl) phenyl]‐1, 2, 4‐
triazoles (5a-d) were obtained by treating m‐(aralkyl amido/imidoalkyl) benzoic acid …

Afacile synthesis of 3, 6-disubstituted-1, 2, 4-triazolo-[3, 4-b]-1, 3, 4-thiadiazoles (5a-j) has
been achieved by condensing 3-aryl substituted 4-amino-5-mercapto (4H)-1, 2, 4-triazole …

Unusual reaction proceeding via the electrophilic activation of nitroalkanes in the presence
of polyphosphoric acid has been discovered. Subsequent nucleophilic attack with …

There is an urgent need for the design and development of new and safer drugs for the
treatment of HIV infection, active against the currently resistant viral strains. New derivatives …