With the advent of transgenic and other genetic engineering technologies, the versatility and
usefulness of the mouse as a model in biomedical research has soared. Revised to reflect …

The influence of protocol standardization between laboratories on their replicability of
preclinical results has not been addressed in a systematic way. While standardization is …

Over recent decades, progress in bioscience research has been remarkable, but alongside
the many transformative advances is a growing concern that a surprisingly high fraction of …

Theoretical and empirical evidence indicates that low external validity due to rigorous
standardization of study populations is a cause of poor replicability in animal research. Here …

In laboratory animal facilities, it is a common code of practice to house female mice in
groups. However, some experimental conditions require to house them individually, even …

Evidence exists that behavioral patterns only stabilize once mice reach adulthood. Detailed
information about the course of behavioral patterns is of particular relevance for …

It is now well‐established that the hippocampal CA2 region plays an important role in social
recognition memory in adult mice. The CA2 is also important for the earliest social …

Metabolic cage housing which is exposed to a number of environmental stressors is often
used in pharmacokinetic studies. In this study, we compared the difference in stress …

Introduction: Single housing of laboratory mice is a common practice to meet experimental
needs, or to avoid intermale aggression. However, single housing is considered to …

There have been increasingly lively discussions about many published scientific results
failing validation by independent studies. This so-called reproducibility crisis has led to …