To predict, prevent, and manage post-traumatic stress disorder (PTSD): a review of pathophysiology, treatment, and biomarkers

GI Al Jowf, ZT Ahmed, RA Reijnders, L de Nijs… - International journal of …, 2023‏ - mdpi.com
Post-traumatic stress disorder (PTSD) can become a chronic and severely disabling
condition resulting in a reduced quality of life and increased economic burden. The disorder …

The corticotropin-releasing factor family: physiology of the stress response

JM Deussing, A Chen - Physiological reviews, 2018‏ - journals.physiology.org
The physiological stress response is responsible for the maintenance of homeostasis in the
presence of real or perceived challenges. In this function, the brain activates adaptive …

The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress

SM Smith, WW Vale - Dialogues in clinical neuroscience, 2006‏ - Taylor & Francis
Animals respond to stress by activating a wide array of behavioral and physiological
responses that are collectively referred to as the stress response. Corticotropin-releasing …

The neuro-symphony of stress

M Joëls, TZ Baram - Nature reviews neuroscience, 2009‏ - nature.com
The impact of stress on brain function is increasingly recognized. Various substances are
released in response to stress and can influence distinct neuronal circuits, but the functional …

Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress

DS Charney - American journal of Psychiatry, 2004‏ - psychiatryonline.org
OBJECTIVE: Most research on the effects of severe psychological stress has focused on
stress-related psychopathology. Here, the author develops psychobiological models of …

The corticosteroid receptor hypothesis of depression

F Holsboer - Depression, 2013‏ - taylorfrancis.com
Signs and symptoms that are characteristic for depression include changes in the setpoint of
the hypothalamic-pituitary-adrenocortical (HPA) system, which in the majority of these …

Neurobiological and psychiatric consequences of child abuse and neglect

C Heim, M Shugart, WE Craighead… - Developmental …, 2010‏ - Wiley Online Library
The effects of early‐life trauma and its consequences for the treatment of depression are
reviewed. The prevalence and clinical sequelae of early sexual and physical abuse, neglect …

Adapting to stress: understanding the neurobiology of resilience

C Osório, T Probert, E Jones, AH Young… - Behavioral …, 2017‏ - Taylor & Francis
There is significant variation in the way individuals react and respond to extreme stress and
adversity. While some individuals develop psychiatric conditions such as posttraumatic …

Region-specific roles of the corticotropin-releasing factor–urocortin system in stress

MJAG Henckens, JM Deussing, A Chen - Nature Reviews …, 2016‏ - nature.com
Dysregulation of the corticotropin-releasing factor (CRF)–urocortin (UCN) system has been
implicated in stress-related psychopathologies such as depression and anxiety. It has been …

CRF and CRF receptors: role in stress responsivity and other behaviors

TL Bale, WW Vale - Annu. Rev. Pharmacol. Toxicol., 2004‏ - annualreviews.org
Since corticotropin-releasing factor (CRF) was first characterized, a growing family of ligands
and receptors has evolved. The mammalian family members include CRF, urocortinI (UcnI) …