Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …
dependent dementia. There is currently no effective treatment for AD, which may be …
Converging pathways in neurodegeneration, from genetics to mechanisms
L Gan, MR Cookson, L Petrucelli, AR La Spada - Nature neuroscience, 2018 - nature.com
Neurodegenerative diseases cause progressive loss of cognitive and/or motor function and
pose major challenges for societies with rapidly aging populations. Human genetics studies …
pose major challenges for societies with rapidly aging populations. Human genetics studies …
TREM2 is a receptor for β-amyloid that mediates microglial function
Mutations in triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to
increased Alzheimer's disease (AD) risk. Neurobiological functions of TREM2 and its …
increased Alzheimer's disease (AD) risk. Neurobiological functions of TREM2 and its …
Propagation of tau aggregates and neurodegeneration
A pathway from the natively unfolded microtubule-associated protein Tau to a highly
structured amyloid fibril underlies human Tauopathies. This ordered assembly causes …
structured amyloid fibril underlies human Tauopathies. This ordered assembly causes …
Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy
Accumulation of hyperphosphorylated tau directly correlates with cognitive decline in
Alzheimer's disease and other primary tauopathies. One therapeutic strategy may be to …
Alzheimer's disease and other primary tauopathies. One therapeutic strategy may be to …
Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches
Progressive supranuclear palsy (PSP), previously believed to be a common cause of
atypical parkinsonism, is now recognised as a range of motor and behavioural syndromes …
atypical parkinsonism, is now recognised as a range of motor and behavioural syndromes …
Evolving concepts in progressive supranuclear palsy and other 4-repeat tauopathies
M Stamelou, G Respondek, N Giagkou… - Nature Reviews …, 2021 - nature.com
Tauopathies are classified according to whether tau deposits predominantly contain tau
isoforms with three or four repeats of the microtubule-binding domain. Those in which four …
isoforms with three or four repeats of the microtubule-binding domain. Those in which four …
Possible mechanisms of tau spread and toxicity in Alzheimer's disease
H Zhang, Y Cao, L Ma, Y Wei, H Li - Frontiers in cell and …, 2021 - frontiersin.org
Tau is a protein that associates with microtubules (MTs) and promotes their assembly and
stability. The protein loses its ability to bind MTs in tauopathies, and detached tau can …
stability. The protein loses its ability to bind MTs in tauopathies, and detached tau can …
Four-repeat tauopathies
Tau is a microtubule-associated protein with versatile functions in the dynamic assembly of
the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative …
the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative …
The new genetic landscape of Alzheimer's disease: from amyloid cascade to genetically driven synaptic failure hypothesis?
Abstract A strong genetic predisposition (60–80% of attributable risk) is present in
Alzheimer's disease (AD). In view of this major genetic component, identification of the …
Alzheimer's disease (AD). In view of this major genetic component, identification of the …