Conflicting reports about whether adult hippocampal neurogenesis occurs in humans raise
questions about its significance for human health and the relevance of animal models …

In the adult hippocampus new neurons are continuously generated throughout life and
integrate into the existing network via the formation of thousands of new synapses. Adult …

A strong GABAergic tone imposes sparse levels of activity in the dentate gyrus of the
hippocampus. This balance is challenged by the addition of new granule cells (GCs) with …

Pattern separation is a process that minimizes overlap between patterns of neuronal activity
representing similar experiences. Theoretical work suggests that the dentate gyrus (DG) …

The dentate gyrus (DG) is the primary gate of the hippocampus and controls information flow
from the cortex to the hippocampus proper. To maintain normal function, granule cells (GCs) …

Pattern separation is a central concept in current theories of episodic memory: this
computation is thought to support our ability to avoid confusion between similar memories by …

Activity‐regulated gene (ARG) expression patterns in the hippocampus (HPC) regulate
synaptic plasticity, learning, and memory, and are linked to both risk and treatment …

Compartmental models are the theoretical tool of choice for understanding single neuron
computations. However, many models are incomplete, built ad hoc and require tuning for …

Neurogenesis persists throughout life in the dentate gyrus region of the mammalian
hippocampus. Computational models have established that the addition of neurons …

Hippocampal adult neurogenesis results in the persisting formation of new neurons that
contribute to hippocampal‐dependent learning and memory. This has led to the hypothesis …