Amyloid proteins can aggregate into insoluble fibrils and form amyloid deposits in the
human brain, which is the hallmark of many neurodegenerative diseases. Promising …

Over a century has passed since Alois Alzheimer first described Alzheimer's disease (AD),
and since then, researchers have made significant strides in understanding its pathology …

Peptide drugs play an essential role in modern therapeutics, but the computational design of
these molecules is hindered by several challenges. Traditional methods like molecular …

Amyloid formation by proteins and peptides is the hallmark of many diseases. Growing
evidence suggests that oligomeric species arising during aggregation are toxic, but the …

Amyloid-β (Aβ) oligomers, particularly low molecular weight (LMW) oligomers, rather than
fibrils, contribute very significantly to the onset and progression of Alzheimer's Disease (AD) …

Phenol-soluble modulins (PSMs) are virulent peptides secreted by staphylococci that
undergo self-assembly into amyloid fibrils. This study focuses on Staphylococcus aureus …

Inhibition of amyloid‐β peptide (Aβ) aggregation is a promising therapeutic strategy for
Alzheimer's disease (AD), as Aβ aggregation is generally believed to trigger AD pathology …

Oligomeric amyloid-β aggregates (AβOs) effectively trigger Alzheimer's disease-related
toxicity, generating great interest in understanding their structures and formation …

Sickle cell disease (SCD) is a group of inherited disorders affecting red blood cells, which is
caused by a single mutation that results in substitution of the amino acid valine for glutamic …

Probing the structures of amyloid‐β (Aβ) peptides in the early steps of aggregation is
extremely difficult experimentally and computationally. Yet, this knowledge is extremely …