Lupus nephritis

HJ Anders, R Saxena, M Zhao, I Parodis… - Nature reviews Disease …, 2020 - nature.com
Lupus nephritis (LN) is a form of glomerulonephritis that constitutes one of the most severe
organ manifestations of the autoimmune disease systemic lupus erythematosus (SLE). Most …

The role of neutrophils and NETosis in autoimmune and renal diseases

S Gupta, MJ Kaplan - Nature Reviews Nephrology, 2016 - nature.com
Systemic autoimmune diseases are a group of disorders characterized by a failure in self-
tolerance to a wide variety of autoantigens. In genetically predisposed individuals, these …

Gut microbiota dysbiosis in systemic lupus erythematosus: novel insights into mechanisms and promising therapeutic strategies

Q Pan, F Guo, Y Huang, A Li, S Chen, J Chen… - Frontiers in …, 2021 - frontiersin.org
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that was traditionally
thought to be closely related to genetic and environmental risk factors. Although treatment …

Diagnosing antiphospholipid syndrome:'extra-criteria'manifestations and technical advances

S Sciascia, MC Amigo, D Roccatello… - Nature Reviews …, 2017 - nature.com
First described in the early 1980s, antiphospholipid syndrome (APS) is a unique form of
acquired autoimmune thrombophilia in which patients present with clinical features of …

Secondary thrombotic microangiopathy in systemic lupus erythematosus and antiphospholipid syndrome, the role of complement and use of eculizumab: case series …

N Kello, L El Khoury, G Marder, R Furie… - Seminars in arthritis and …, 2019 - Elsevier
Introduction Thrombotic microangiopathy (TMA) is a life-threatening, albeit infrequent,
complication of systemic lupus erythematosus (SLE) and anti-phospholipid syndrome (APS) …

Autoantibodies in SLE: specificities, isotypes and receptors

B Dema, N Charles - Antibodies, 2016 - mdpi.com
Systemic Lupus Erythematosus (SLE) is characterized by a wide spectrum of auto-
antibodies which recognize several cellular components. The production of these self …

Antiphospholipid syndrome: role of vascular endothelial cells and implications for risk stratification and targeted therapeutics

MT Corban, A Duarte-Garcia, RD McBane… - Journal of the American …, 2017 - jacc.org
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by venous
thromboembolism, arterial thrombosis, and obstetric morbidities in the setting of persistently …

The antiphospholipid syndrome: from pathophysiology to treatment

S Negrini, F Pappalardo, G Murdaca, F Indiveri… - Clinical and …, 2017 - Springer
Antiphospholipid antibody syndrome (APS) is an autoimmune acquired thrombophilia
characterized by recurrent thrombosis and pregnancy morbidity in the presence of …

Antiphospholipid syndrome–an update

B Linnemann - Vasa, 2018 - econtent.hogrefe.com
Antiphospholipid syndrome (APS) is an autoantibody-mediated acquired thrombophilia. It is
characterized by the presence of antiphospholipid antibodies (APL) that are directed against …

Current treatment of antiphospholipid syndrome: lights and shadows

G Espinosa, R Cervera - Nature Reviews Rheumatology, 2015 - nature.com
For patients with antiphospholipid syndrome (APS), the consensus is to treat those who
develop thrombosis with long-term oral anticoagulation therapy and to prevent obstetric …