Research into the potential benefits of artificial intelligence for comprehending the intricate
biology of cancer has grown as a result of the widespread use of deep learning and …

Background The widespread use of Immune checkpoint-inhibitors (ICI) has revolutionised
treatment of multiple cancer types. However, selecting patients who may benefit from ICI …

Background The epigenetic regulatory chemical lactate is a product of glycolysis. It can
regulate gene expression through histone lactylation, thereby promoting tumor proliferation …

Growing evidence indicates a connection between cancer-associated fibroblasts (CAFs)
and tumor microenvironment (TME) remodeling and tumor progression. Nevertheless, how …

Progress in sequencing technologies and clinical experiments has revolutionized
immunotherapy on solid and hematologic malignancies. However, the benefits of …

Background Tertiary lymphoid structure (TLS) is a unique organ that carries out tumor cell
elimination at tumor sites. It is continuously stimulated by inflammatory tumor signals and …

Glioblastoma (GBM) progression is influenced by intratumoral heterogeneity. Emerging
evidence has emphasized the pivotal role of extrachromosomal circular DNA (eccDNA) in …

The widespread use of high-throughput sequencing technologies has revolutionized the
understanding of biology and cancer heterogeneity. Recently, several machine-learning …

Decades of research have investigated the mechanisms that lead to the origin of cancer,
striving to identify tumor-initiating cells. These cells, also known as cancer stem cells, are …

Triple-negative breast cancer (TNBC) is a relatively aggressive breast cancer subtype due to
tumor relapse, drug resistance, and multi-organ metastatic properties. Identifying reliable …